Albumin has consistently demonstrated its potential for enhancing the delivery of drugs and polymer–drug conjugates, binding via supramolecular forces within its multiple binding sites. Herein, we introduce saturation transfer difference (STD-NMR) as a method to identify the interactions between a polymer library and bovine serum albumin (BSA). With STD-NMR, the binding ability of polymers can be quickly screened by focusing on their individual structural features, making this technique more suitable for high throughput screening in comparison to traditional fluorescence studies.

中文翻译：

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用于阐明超分子白蛋白-聚合物相互作用的饱和转移差核磁共振光谱

白蛋白一直证明其增强药物和聚合物-药物偶联物递送的潜力，通过其多个结合位点内的超分子力结合。在这里，我们引入饱和转移差异 (STD-NMR) 作为一种方法来识别聚合物库和牛血清白蛋白 (BSA) 之间的相互作用。使用 STD-NMR，可以通过关注其各自的结构特征来快速筛选聚合物的结合能力，与传统的荧光研究相比，该技术更适合高通量筛选。