Results from studies of the local anesthetic activity of a gel for surface anesthesia that was developed at A. S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan are presented. DF Skincaine gel (Korea) and 5% lidocaine solution were used as reference drugs. A model of terminal anesthesia of rabbit-eye cornea showed that the test gel had a local anesthetic effect with a Rainier index of 950; DF Skincaine gel, 680; 5% lidocaine solution, 480. The new gel had a longer anesthetic effect than DF Skincaine (75 ± 6.4 and 45 ± 3.8 mins or 66.7% longer) and shorter latent period (4 and 6 min or 37% less). The studies showed that instillation into the conjunctival sac of the anesthetic gel did not cause adverse local reactions. Conversely, use of 5% lidocaine solution as an anesthetic agent led to the appearance of signs of local irritation as hyperemia of the conjunctivae and edge of the eyelids. Results of acute toxicity tests after subcutaneous injection to mice showed that the anesthetic gel was seven times less toxic than 5% lidocaine solution. The LD₅₀ values of the compounds were lidocaine 274.6 ± 7.4 mg/kg; DF Skincaine, ≥2000; and the new anesthetic gel, ≥2500.

介绍了乌兹别克斯坦共和国科学院 AS Sadykov 生物有机化学研究所开发的用于表面麻醉的凝胶局部麻醉活性的研究结果。DF Skincaine 凝胶（韩国）和 5% 利多卡因溶液用作参比药物。兔眼角膜终末麻醉模型显示，试验凝胶具有局麻作用，雷尼尔指数为950；DF Skincaine 凝胶，680；5% 利多卡因溶液，480。新凝胶的麻醉效果比 DF Skincaine 长（75 ± 6.4 和 45 ± 3.8 分钟或长 66.7%）和更短的潜伏期（4 和 6 分钟或少 37%）。研究表明，将麻醉凝胶滴入结膜囊不会引起局部不良反应。反过来，使用 5% 利多卡因溶液作为麻醉剂导致结膜和眼睑边缘充血等局部刺激迹象的出现。小鼠皮下注射后的急性毒性试验结果表明，麻醉凝胶的毒性比 5% 利多卡因溶液低 7 倍。LD_{50 个}化合物的值为利多卡因 274.6 ± 7.4 mg/kg；DF Skincaine，≥2000；和新的麻醉凝胶，≥2500。