A new method of mathematical modeling called Sediment Delivery Model (SeDeM) is reviewed. This method is a convenient tool for determining the suitability of powdered material for direct compression. The method identifies unsatisfactory properties of the material and also determines the type and amount of excipients that should be added to the tablet formulation to neutralize the unsatisfactory properties of the active pharmaceutical ingredient (API). The principles of application of the SeDeM method are considered. The parameters to be determined for application of this method, the equations for calculations, and the constructed diagrams are presented. The methods for application of SeDeM to the pharmaceutical industry and the advantages of such use of the system are described. The SeDeM method is used to optimize and calculate the composition of tablets obtained by direct compression. This system takes into account all the characteristics of the bulk material and provides recommendations for the selection of excipients. The method makes it easier to develop a new drug and simplifies the manufacturing process by eliminating unnecessary excipients. In addition, the method is used for quality control of single APIs and excipients.

回顾了一种称为沉积物输送模型 (SeDeM) 的数学建模新方法。该方法是一种方便的工具，可用于确定粉末材料是否适合直接压缩。该方法确定了材料的不令人满意的特性，并确定了应添加到片剂配方中的赋形剂的类型和数量，以中和活性药物成分 (API) 的不令人满意的特性。考虑了 SeDeM 方法的应用原理。给出了为应用该方法而确定的参数、计算方程和构建的图表。描述了将 SeDeM 应用于制药行业的方法以及使用该系统的优势。SeDeM 方法用于优化和计算直接压片获得的片剂的组成。该系统考虑了散装材料的所有特性，并为辅料的选择提供建议。该方法通过消除不必要的赋形剂使新药的开发变得更容易，并简化了制造过程。此外，该方法用于单一原料药和赋形剂的质量控制。