Deep eutectic solvents (DESs) were used as environmentally benign and straightforward replacements for the harmful organic solvents and transition metal-based catalysts in various organic syntheses. Here, we report a DES as a mild, biocompatible, and environmentally friendly dual solvent/catalyst for the one-pot construction of 2-amino-5-alkylidenethiazol-4-ones throw one-pot reaction of carbonyl compounds, nitrogen compounds, and rhodanine up to quantitative yields within a latent period of times. This green procedure has a more diverse and broader scope regarding starting materials and exhibits excellent conversion and high selectivity. In particular, DES displays better durability and reusability in the multicomponent reactions than traditional catalysts and solvents without distinct deterioration in catalytic activity.

深共熔溶剂 (DES) 被用作各种有机合成中有害有机溶剂和过渡金属基催化剂的环境友好且直接的替代品。在这里，我们报告了 DES 作为一种温和、生物相容性和环境友好的双溶剂/催化剂，用于 2-amino-5-alkylidenethiazol-4-ones 的一锅构建羰基化合物、氮化合物和罗丹宁在潜伏期内达到定量产量。这种绿色程序在起始原料方面具有更多样化和更广泛的范围，并表现出优异的转化率和高选择性。特别是，DES 在多组分反应中表现出比传统催化剂和溶剂更好的耐久性和可重复使用性，而催化活性没有明显下降。