In the article by Liu et al., “Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure,” which published on February 1, 2021, and appeared in the February 2021 issue of the journal (Circulation: Genomic and Precision Medicine. 2021;14:e003142. 10.1161/CIRCGEN.120.003142), corrections were needed.

The downregulation of the differentially expressed genes (DEG) in DCM and HCM was erroneously taken from the DEGs with 2 fold changes instead of 1.5 fold changes. The number of genes downregulated ≥ 1.5 fold is 289 (3% of the expressed genes) and 333 (3.4% of the expressed genes) in DCM and HCM, respectively. Thus, there were 1094 (11.5% of differentially expressed genes, [DEGs]) and 1473 (15.5%) DEGs in DCM and HCM, respectively. Out of 1661 DEGs, 755 (45%) genes were expressed uniquely in DCM or HCM. For downregulated DGEs, Gene Ontology (GO) analysis revealed that amino acid metabolism, cell cycle, and gene expression were linked to DCM. In contrast, only one GO team, organismal functions, was linked to HCM specifically.

Figure panels C and D have been revised accordingly. There were no changes to figure legends. The percentage of upregulation DEG in DCM is corrected to 8.5%. The change does not affect the scientific conclusion in this article.

The authors regret these errors.

This correction has been made to the current online version of the article, which is available at https://www.ahajournals.org/doi/10.1161/CIRCGEN.120.003142.

在 Liu 等人的文章中，“Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in different Cardiomyopathy Subtypes of Heart Failure”，该文章发表于 2021 年 2 月 1 日，并出现在 2021 年 2 月的期刊上期刊 ( Circulation: Genomic and Precision Medicine. 2021;14:e003142.10.1161/CIRCGEN.120.003142)，需要更正。

DCM 和 HCM 中差异表达基因 (DEG) 的下调错误地取自具有 2 倍变化而不是 1.5 倍变化的 DEG。在 DCM 和 HCM 中，下调≥ 1.5 倍的基因数量分别为 289（表达基因的 3%）和 333（表达基因的 3.4%）。因此，DCM 和 HCM 中分别有 1094 个（11.5% 的差异表达基因，[DEG]）和 1473 个（15.5%）DEG。在 1661 个 DEG 中，755 个（45%）基因在 DCM 或 HCM 中唯一表达。对于下调的 DGE，基因本体论 (GO) 分析显示氨基酸代谢、细胞周期和基因表达与 DCM 相关。相比之下，只有一个 GO 团队，即有机体功能，与 HCM 相关。

图面板 C 和 D 已相应修改。人物图例没有变化。DCM 中上调 DEG 的百分比校正为 8.5%。该变化不影响本文的科学结论。

作者对这些错误表示遗憾。

此更正已对文章的当前在线版本进行了更正，该版本可在 https://www.ahajournals.org/doi/10.1161/CIRCGEN.120.003142 上获得。