Benzophenone-3 (BP-3) is one of the most used UV filters. The present study aimed to evaluate the toxic effects of BP-3 during embryo stages of zebrafish four hours post-fertilization (4hpf). Embryos were exposed to 0, 1, and 10 µg L⁻¹ of BP-3 for 72 h. We investigated biochemical and molecular biomarkers of neurotoxicity (AChE) and the antioxidant system (gene expression of catalase, CAT, superoxide dismutase, SOD, glutathione peroxidase, GPX, the concentration of total glutathione, GSH, and lipid hydroperoxides, LPO). Results indicated that the acute exposure to BP-3 in zebrafish embryos did not show significant differences in survival, hatching rate, or antioxidant system biomarkers. In contrast, there were significant differences associated with AChE gene expression and activity.

二苯甲酮-3 (BP-3) 是最常用的紫外线过滤剂之一。本研究旨在评估 BP-3 在受精后 4 小时 (4hpf) 斑马鱼胚胎阶段的毒性作用。胚胎暴露于 0、1 和 10 µg L ^-1的 BP-3 72 小时。我们研究了神经毒性 (AChE) 和抗氧化系统的生化和分子生物标志物（过氧化氢酶、CAT、超氧化物歧化酶、SOD、谷胱甘肽过氧化物酶、GPX、总谷胱甘肽、GSH 和脂质氢过氧化物 LPO 的浓度）的基因表达。结果表明，斑马鱼胚胎中 BP-3 的急性暴露在存活率、孵化率或抗氧化系统生物标志物方面没有显着差异。相反，与 AChE 基因表达和活性相关的显着差异。