Abstract

The review summarizes the results of studies on the cellular and molecular mechanisms mediating the impact of stress on the pathogenesis of neurodegenerative brain pathologies (Alzheimer’s disease, Parkinson’s disease, etc.) and presents current information on the role of stress in the hyperphosphorylation of tau protein, aggregation of beta‑amyloid, and hyperactivation of the hypothalamic-pituitary-adrenal axis involved in the hyperproduction of factors that contribute to the pathogenetic role of stress in neurodegeneration. The data on the participation of microglia in the effects of stress on the pathogenesis of neurodegenerative diseases are presented.

中文翻译：

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当前关于压力在慢性神经退行性疾病发病机制中的作用的观点

摘要

该综述总结了有关介导压力对神经退行性脑病（阿尔茨海默病、帕金森病等）发病机制影响的细胞和分子机制的研究结果，并提供了有关压力在 tau 蛋白过度磷酸化中的作用的最新信息、β-淀粉样蛋白的聚集和下丘脑-垂体-肾上腺轴的过度激活，这些轴参与了导致压力在神经变性中的致病作用的因子的过度产生。介绍了小胶质细胞参与压力对神经退行性疾病发病机制的影响的数据。