Abstract

Comparative analysis of available literature data on the pathogenetic neuroendocrine mechanisms of depression and post-traumatic stress disorder (PTSD) is provided in this review to identify their common features and differences. We discuss the multidirectional modifications of the activity of cortical and subcortical structures of the brain, levels of neurotransmitters and their receptors, and functions of the hypothalamic-pituitary-adrenocortical axis in depression and PTSD. The analysis shows that these disorders are examples of opposite failures in the system of adaptive stress response of the body to stressful psychotraumatic events. On this basis, it is concluded that the currently widespread use of similar approaches to treat these disorders is not justified, despite the significant similarity of their anxiety-depressive symptoms; development of differential therapeutic strategies is required.

中文翻译：

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重度抑郁症与创伤后应激障碍的病理生化变化比较分析

摘要

本综述提供了关于抑郁症和创伤后应激障碍 (PTSD) 发病神经内分泌机制的现有文献数据的比较分析，以确定它们的共同特征和差异。我们讨论了大脑皮层和皮层下结构的活动、神经递质及其受体的水平以及下丘脑-垂体-肾上腺皮质轴在抑郁症和 PTSD 中的功能的多向改变。分析表明，这些疾病是身体对压力性心理创伤事件的适应性压力反应系统出现相反故障的例子。在此基础上，得出的结论是，目前广泛使用类似方法来治疗这些疾病是不合理的，尽管它们的焦虑抑郁症状非常相似；