The aim of the present study was to evaluate the anesthetic and cardiopulmonary effects of dexmedetomidine in combination with tiletamine (without zolazepam) as a general anesthetic. The study was divided into two phases. In Phase 1, eighteen adult healthy mixed-breed dogs were randomly allocated into three groups: Group TD8 (4.5 mg kg-1 tiletamine and 8 μg kg-1 dexmedetomidine), Group TD10 (4.5 mg kg-1 tiletamine and 10 μg kg-1 dexmedetomidine), or Group TD12 (4.5 mg kg-1 tiletamine and 12 μg kg-1 dexmedetomidine). After drug administration, the heart rate (HR), respiratory rate (fR), mean arterial pressure (MAP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), peripheral hemoglobin oxygen saturation (SpO2), behavioral score, quality of induction and recovery, extent of ataxia, and the time taken for induction and the duration of anesthesia were recorded. The recovery time and quality were recorded after administration of atipamezole (50 μg kg-1) after 60 minutes. In phase 2, the feasibility of combining dexmedetomidine (10 μg kg-1) and tiletamine (4.5 mg kg-1) as general anesthetics was evaluated in dogs (n = 6). HR, fR, MAP, SAP, DAP, Temperature, SpO2, behavioral scores, and adverse reactions were recorded during each surgical procedure. In phase 1, the dogs were anesthetized for 5 minutes after administration of drugs and achieved a maximum behavioral score in TD10 and TD12 after 10 min. Although HR, MAP, SAP, DAP, and NIBP decreased in all three groups, they remained within the normal range. In phase 2, orchiectomy was completed smoothly in all dogs with little fluctuation in the physiological variables. We found that a combination of tiletamine (4.5 mg kg-1) and dexmedetomidine (10 μg kg-1) administered intramuscularly induced moderate anesthesia in dogs and could be utilized for short-term anesthesia and minor surgery.

中文翻译：

---

右美托咪定-替他明对犬的心肺（非通气）和麻醉作用

本研究的目的是评估右美托咪定联合替他明（不含唑拉西泮）作为全身麻醉剂的麻醉和心肺作用。研究分为两个阶段。在第 1 阶段，18 只成年健康混种犬被随机分为三组：TD8 组（4.5 mg kg-1 tiletamine 和 8 μg kg-1 右美托咪定），TD10 组（4.5 mg kg-1 tiletamine 和 10 μg kg- 1 右美托咪定），或 TD12 组（4.5 mg kg-1 tiletamine 和 12 μg kg-1 右美托咪定）。给药后心率（HR）、呼吸频率（fR）、平均动脉压（MAP）、收缩压（SAP）、舒张压（DAP）、外周血红蛋白氧饱和度（SpO2）、行为评分、质量诱导和恢复，共济失调的程度，并记录诱导时间和麻醉持续时间。在 60 分钟后记录阿替美唑 (50 μg kg-1) 给药后的恢复时间和质量。在第 2 阶段，在狗 (n = 6) 中评估了将右美托咪定 (10 μg kg-1) 和 tiletamine (4.5 mg kg-1) 组合作为全身麻醉剂的可行性。在每次手术过程中记录 HR、fR、M​​AP、SAP、DAP、温度、SpO2、行为评分和不良反应。在第 1 阶段，狗在给药后麻醉 5 分钟，并在 10 分钟后达到 TD10 和 TD12 的最大行为评分。尽管所有三组的 HR、MAP、SAP、DAP 和 NIBP 均有所下降，但仍保持在正常范围内。在第 2 阶段，所有狗的睾丸切除术都顺利完成，生理变量几乎没有波动。