Proper development and plasticity of hippocampal neurons require specific RNA isoforms to be expressed in the right place at the right time. Precise spatiotemporal transcript regulation requires the incorporation of essential regulatory RNA sequences into expressed isoforms. In this review, we describe several RNA processing strategies utilized by hippocampal neurons to regulate the spatiotemporal expression of genes critical to development and plasticity. The works described here demonstrate how the hippocampus is an ideal investigative model for uncovering alternate isoform-specific mechanisms that restrict expression of transcripts in space and time.

中文翻译：

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海马转录本异构体表达的时空调控

海马神经元的正常发育和可塑性需要特定的 RNA 异构体在正确的时间在正确的位置表达。精确的时空转录调控需要将必要的调控 RNA 序列整合到表达的同种型中。在这篇综述中，我们描述了海马神经元用来调节对发育和可塑性至关重要的基因的时空表达的几种 RNA 加工策略。此处描述的作品展示了海马体如何成为揭示限制转录本在空间和时间中表达的替代异构体特异性机制的理想研究模型。