Peptide nucleic acids and their role in gene regulation and editing,Biopolymers

当前位置： X-MOL 学术 › Biopolymers › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Peptide nucleic acids and their role in gene regulation and editing
Biopolymers ( IF 3.2 ) Pub Date : 2021-06-15 , DOI: 10.1002/bip.23460
J Dinithi R Perera ₁ , Kelly E W Carufe ₁ , Peter M Glazer _{1,

2}

Affiliation

The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be used in therapeutic and biotechnological interventions. It has been broadly utilized for numerous applications, with a major focus in regulation of gene expression, and more recently in gene editing. While the classic PNA design has mainly been employed to date, chemical modifications of the PNA backbone and nucleobases provide an avenue to advance the technology further. This review aims to discuss the recent developments in PNA based gene manipulation techniques and the use of novel chemical modifications to improve the current state of PNA mediated gene targeting.

中文翻译：

肽核酸及其在基因调控和编辑中的作用

肽核酸 (PNA) 的独特特性使其成为用于治疗和生物技术干预的理想候选者。它已被广泛用于许多应用，主要集中在基因表达的调节，最近还用于基因编辑。虽然迄今为止主要采用经典的 PNA 设计，但 PNA 主链和核碱基的化学修饰为进一步推进该技术提供了途径。本综述旨在讨论基于 PNA 的基因操作技术的最新发展以及使用新的化学修饰来改善 PNA 介导的基因靶向的现状。

更新日期：2021-06-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11