Model-free leakage index estimation of the blood-brain barrier using dual dynamic susceptibility contrast MRI acquisition,NMR in Biomedicine

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Model-free leakage index estimation of the blood-brain barrier using dual dynamic susceptibility contrast MRI acquisition
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-06-15 , DOI: 10.1002/nbm.4570
Seokha Jin ₁ , Hyung Joon Cho ₁

Affiliation

Pharmacokinetic K₂ mapping from dynamic susceptibility contrast (DSC)-MRI can be a sensitive technique for evaluating the vascular permeability of the subtly damaged blood-brain barrier (BBB) in ischemic regions. However, the K₂ values of ischemic lesions depend upon the selection of the intact BBB reference region. As previous observations suggest that the ΔR₂^* curve of pre-loaded DSC-MRI is not significantly affected by the extravasation of contrast agent, dual DSC-MRI acquisitions can be performed to derive the BBB leakage index from the voxel-wise reference input function for ischemic regions. This study aims to demonstrate the robustness of such model-free leakage index estimation in ischemic brains. By configuring the relationship between dual ΔR₂^* curves of the intact contralateral brain, the deviation of the measured ΔR₂^* curve from the unloaded DSC-MRI with respect to the non-deviated ΔR₂^* curve in the pre-loaded DSC-MRI can be quantified as the BBB leakage index. Such model-free leakage index values from rats with transient middle carotid artery occlusion (tMCAO) (n = 17) and normal controls (n = 3) were evaluated and compared with conventional K₂ values with multiple reference regions. Inter-subject leakage index values were also compared with the corresponding ΔT₁ map. Evans-blue-stained images were used to validate the leakage index. For the tMCAO group, leakage index values correlated well with ΔT₁ (Pearson's r = 0.828). The hyperintense area on the leakage index map matched well with the corresponding Evans-blue-stained area (Dice correlation = 0.626). The slopes of the scatter-plot from the leakage index (0.97-1.00) were observed to be more robust against changes in the reference region than those from conventional K₂ values (0.94-1.07). In a subtly damaged BBB tMCAO model, model-free evaluation of vascular permeability using dual DSC-MRIs would provide a consistent measure of inter-subject vascular permeability.

中文翻译：

使用双动态磁化率对比 MRI 采集对血脑屏障进行无模型渗漏指数估计

动态磁敏对比 (DSC)-MRI 的药代动力学K ₂绘图可以成为评估缺血区域轻微受损的血脑屏障 (BBB) 血管通透性的敏感技术。然而，缺血性病变的K ₂值取决于完整BBB参考区域的选择。由于先前的观察表明预加载 DSC-MRI 的 Δ R ₂ ^*曲线不受造影剂外渗的显着影响，因此可以执行双 DSC-MRI 采集，以从体素参考输入导出 BBB 泄漏指数对缺血区域有作用。本研究旨在证明这种无模型渗漏指数估计在缺血性大脑中的稳健性。通过配置完整对侧大脑的双 Δ R ₂ ^*曲线之间的关系，测量未加载 DSC-MRI 的 Δ R ₂ ^*曲线相对于预加载中未偏离的 Δ R ₂ ^*曲线的偏差DSC-MRI 可量化为 BBB 渗漏指数。对来自短暂性颈动脉中动脉闭塞 (tMCAO) ( n = 17) 和正常对照 ( n = 3) 的大鼠的此类无模型渗漏指数值进行了评估，并与多个参考区域的传统K ₂值进行比较。受试者间泄漏指数值也与相应的ΔT ₁图进行比较。使用伊文思蓝染色图像来验证泄漏指数。对于 tMCAO 组，渗漏指数值与 Δ T ₁密切相关（Pearson's r = 0.828）。泄漏指数图上的高信号区域与相应的伊文思蓝染色区域匹配良好（Dice 相关性 = 0.626）。据观察，泄漏指数 (0.97-1.00) 的散点图斜率比传统K ₂值 (0.94-1.07) 的散点图斜率更能抵抗参考区域的变化。在轻微受损的 BBB tMCAO 模型中，使用双 DSC-MRI 对血管通透性进行无模型评估将提供受试者间血管通透性的一致测量。

更新日期：2021-06-15

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