In this study, an innovative bioavailable gingerol formulation, Ginactiv, was prepared by using polar–nonpolar sandwich (PNS) technology with a full spectrum of ginger matrix (FSGM). SEM images showed that Ginactiv was almost spherical, was well dispersed, had a smooth morphology with a particle size range of 50–60 μm, and was divided by three layers of PNS formulation. IR, DSC, a stability study, an enhanced and sustained release profile, and the good antioxidant potential of Ginactiv furthermore confirmed the existence of gingerols with great stability in a bioavailable form in the PNS formulation. Ginactiv registered a higher moisture content (3.98 ± 1.17%), hygroscopicity (0.94 ± 0.23 g/g), and water solubility index (43.71 ± 3.42%) in comparison to the ginger oleoresin values of 1.96 ± 0.72%, 0.36 ± 0.13 g/g, and 9.62 ± 1.21%, respectively, due to the good encapsulation of gingerols by the PNS technology. The existence of the synergistic effects of FSGM in Ginactiv can be utilized as a natural dietary supplement for supporting gastrointestinal and gut health improvement and to maintain the gut–brain axis.

中文翻译：

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使用极性-非极性夹心技术制备和表征新型生物可利用姜酚制剂、其抗氧化潜力和体外释放研究

在这项研究中，使用极性-非极性夹心 (PNS) 技术和全光谱姜基质 (FSGM) 制备了一种创新的生物可利用姜酚制剂 Ginactiv。SEM 图像显示 Ginactiv 几乎呈球形，分散良好，具有光滑的形态，粒径范围为 50-60 μm，并被三层 PNS 制剂分开。IR、DSC、稳定性研究、增强和持续释放曲线以及 Ginactiv 的良好抗氧化潜力进一步证实了 PNS 制剂中存在具有生物可利用性形式的具有高度稳定性的姜酚。与姜油树脂值 1.96 ± 0.72%、0.33 g ± 0.1% 相比，Ginactiv 的水分含量 (3.98 ± 1.17%)、吸湿性 (0.94 ± 0.23 g/g) 和水溶性指数 (43.71 ± 3.42%) 更高/g, 和 9.62 ± 1.21%, 由于 PNS 技术对姜辣素进行了良好的封装。FSGM 在 Ginactiv 中存在的协同作用可用作天然膳食补充剂，以支持胃肠道和肠道健康改善并维持肠脑轴。