Between 1996 and 2020, 12,565 cases were enrolled in the German Registry of Pituitary Tumors including 10,084 PitNETs (10,067 adenomas and 19 carcinomas obtained surgically and 193 adenomas diagnosed at autopsy) as well as 69 spindle cell tumors of the neurohypophysis (64 surgical specimens and 5 autopsies). In six patients (1 post mortem and 5 surgical specimens), PitNETs as well as posterior lobe tumors were found in the specimens. Two of the PitNETs were sparsely granulated prolactin-producing tumors, combined in one case with a granular cell tumor and in one case with a pituicytoma. One of the PitNETs revealed that autopsy was a sparsely granulated GH tumor combined with a neurohypophyseal granular cell tumor. Two PitNETs were null cell adenomas combined with a pituicytoma and a spindle cell oncocytoma, respectively. Further, one Crooke cell tumor was combined with a spindle cell oncocytoma. In five cases, the PitNETs were larger than the posterior lobe tumors and accounted for the clinical symptoms. Previously, four cases of co-existing pituitary anterior and posterior lobe tumors were described in the literature, comprising two ACTH PitNETs, one gonadotrophic PitNET and one null cell PitNET, each in combination with a pituicytoma. PitNETs and concomitant granular cell tumor or spindle cell oncocytoma, as observed in our cohort, have not been reported before.

1996 年至 2020 年间，德国垂体肿瘤登记处登记了 12,565 例病例，包括 10,084 例 PitNETs（10,067 例腺瘤和 19 例手术获得的癌，193 例在尸检时诊断出的腺瘤）以及 69 例神经垂体梭形细胞瘤（64 例手术标本和 5尸检）。在 6 名患者（1 名死后标本和 5 名手术标本）中，标本中发现了 PitNETs 和后叶肿瘤。两个 PitNETs 是稀疏的颗粒状产生催乳素的肿瘤，一例合并颗粒细胞瘤，一例合并垂体细胞瘤。其中一个 PitNET 显示尸检是一个稀疏的颗粒 GH 肿瘤与一个神经垂体颗粒细胞肿瘤相结合。两个 PitNET 分别是空细胞腺瘤与垂体细胞瘤和梭形细胞嗜酸细胞瘤相结合。进一步，一个克鲁克细胞瘤与一个梭形细胞嗜酸细胞瘤相结合。在 5 例中，PitNETs 比后叶肿瘤大，并解释了临床症状。以前，文献中描述了 4 例共存的垂体前叶和后叶肿瘤，包括 2 个 ACTH PitNET、1 个促性腺激素 PitNET 和 1 个空细胞 PitNET，每个都与垂体细胞瘤结合。正如在我们的队列中观察到的，PitNETs 和伴随的颗粒细胞瘤或梭形细胞嗜酸细胞瘤以前没有报道过。一个促性腺激素 PitNET 和一个空细胞 PitNET，每个都与垂体细胞瘤结合。正如在我们的队列中观察到的，PitNETs 和伴随的颗粒细胞瘤或梭形细胞嗜酸细胞瘤以前没有报道过。一个促性腺激素 PitNET 和一个空细胞 PitNET，每个都与垂体细胞瘤结合。正如在我们的队列中观察到的，PitNETs 和伴随的颗粒细胞瘤或梭形细胞嗜酸细胞瘤以前没有报道过。