Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, and “clinical trial”, combined with the search terms “herbs” and “medicinal plants”, in addition to individual herbal medicines by both their common and scientific names. This updated review, which focuses mainly on clinical trials, includes research on 23 medicinal plants and their combinations. Essential oils and their associations have also been reviewed. The efficacy of medicinal plants depends on treatment duration, types of study subjects, administration route, and treatment method. More clinical trials with an adequate, standardized design are necessary, as are more preclinical studies to continue studying the mechanisms of action. As a result of our work, we can conclude that the 3 plants with the most potential are valerian, passionflower, and ashwagandha, with the combination of valerian with hops and passionflower giving the best results in the clinical tests.

中文翻译：

---

治疗与焦虑症相关的失眠的药用植物：最新评论

睡眠障碍在普通人群中很常见，会导致失眠和焦虑等健康问题。除了标准药物和心理干预外，还有不同的补充性植物疗法用于治疗失眠和焦虑。本综述旨在查找和审查根据临床试验汇编的关于使用草药治疗焦虑和失眠的最新研究，并评估这些药物的安全性和有效性，并阐明其可能的作用机制。该过程需要对 2010 年至 2020 年的 PubMed、Scopus 和 Cochrane 图书馆数据库进行搜索。搜索词包括“睡眠障碍”、“失眠”、“镇静”、“催眠”、“焦虑”、“抗焦虑”和“临床试验”，结合搜索词“草药”和“药用植物”，除了个别草药的通用名称和科学名称。此次更新的综述主要侧重于临床试验，包括对 23 种药用植物及其组合的研究。还审查了精油及其关联。药用植物的功效取决于治疗持续时间、研究对象类型、给药途径和治疗方法。需要更多具有充分、标准化设计的临床试验，以及更多的临床前研究以继续研究作用机制。根据我们的工作，我们可以得出结论，最有潜力的 3 种植物是缬草、西番莲和南非醉茄，缬草与啤酒花和西番莲的组合在临床试验中取得了最好的结果。