Surface nanostructuring of bioresorbable polymers is a promising solution for tissue regeneration therapies, as such nanostructured implants non-toxically degrade after producing localized and prolonged stimuli. In this work, a process chain for the fabrication of bioresorbable polymer implants was developed and validated. The implants present surface arrays of nanopillars whose main design parameters were optimized to induce the osteogenic differentiation of human stem cells. In vitro and in vivo cell experiments provided evidence for the potential application in tissue regeneration and revealed that nanopillars' diameter, height, and spacing need to be independently optimized to effectively promote osteogenic differentiation.

生物可吸收聚合物的表面纳米结构是组织再生治疗的一种有前途的解决方案，因为这种纳米结构的植入物在产生局部和长时间的刺激后无毒降解。在这项工作中，开发并验证了用于制造生物可吸收聚合物植入物的工艺链。植入物呈现纳米柱的表面阵列，其主要设计参数经过优化以诱导人类干细胞的成骨分化。体外和体内细胞实验为组织再生的潜在应用提供了证据，并表明纳米柱的直径、高度和间距需要独立优化以有效促进成骨分化。