A mechanism involving endoplasmic reticulum-mitochondria contacts noted in diabetes mellitus may explain the neurodegeneration and amyloidogenesis observed in these patients. Urolithin A, a metabolite found in the gut microbiome, is proposed as a therapeutic strategy for the treatment of the diabetes-related dementia.

中文翻译：

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线粒体-ER 接触和葡萄糖：阿尔茨海默病的动力来源？

糖尿病中发现的涉及内质网-线粒体接触的机制可以解释在这些患者中观察到的神经变性和淀粉样蛋白生成。尿石素 A 是一种在肠道微生物组中发现的代谢物，被提议作为治疗糖尿病相关痴呆的治疗策略。