Members of the HECT family of E3 ubiquitin ligases have emerged as prominent regulators of PTEN function, subcellular localization and levels. In turn this unfolding regulatory network is allowing for the identification of genes directly involved in both tumorigenesis at large and cancer susceptibility syndromes. While the complexity of this regulatory network is still being unraveled, these new findings are paving the way for novel therapeutic modalities for cancer prevention and therapy as well as for other diseases. Here we will review the signal transduction and therapeutic implications of the cross-talk between HECT family members and PTEN.

中文翻译：

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E3 泛素连接酶和 PTEN 的 HECT 家族

E3 泛素连接酶 HECT 家族的成员已成为 PTEN 功能、亚细胞定位和水平的重要调节因子。反过来，这种展开的调控网络可以识别直接参与整个肿瘤发生和癌症易感性综合征的基因。虽然这一监管网络的复杂性仍有待揭开，但这些新发现正在为癌症预防和治疗以及其他疾病的新治疗方式铺平道路。在这里，我们将回顾 HECT 家族成员和 PTEN 之间串扰的信号转导和治疗意义。