Applied Radiation and Isotopes ( IF 1.6 ) Pub Date : 2021-06-12 , DOI: 10.1016/j.apradiso.2021.109825 Jonathan Siikanen 1 , Emma Jussing 2 , Stefan Milton 2 , Carsten Steiger 3 , Johan Ulin 4 , Cathrine Jonsson 5 , Erik Samén 2 , Thuy A Tran 2
The growing need and limited availability of generator produced 68Ga (T1/2 = 68 min) for PET has provided the impetus for alternative, high output, 68Ga production routes such as charge particle activation of enriched 68Zn using PET cyclotrons. The work presents a rapid production method for clinically useful 68Ga for radiolabeling. The focus is also to expand the production capacity of cyclotron solid target-produced 68Ga over generator produced and liquid solutions targets by using enriched 68Zn-foils that minimizes target preparation.
中文翻译:
回旋加速器从富集的 68Zn 箔中产生 68Ga
用于 PET 的68 Ga (T 1/2 = 68 min)发生器的需求不断增长且可用性有限,这为替代的高输出68 Ga 生产路线 提供了动力,例如使用 PET 回旋加速器对富集68 Zn 进行电荷粒子活化。这项工作提出了一种用于放射性标记的临床有用68 Ga的快速生产方法。重点还在于通过使用浓缩的68锌箔,最大限度地减少靶材制备,扩大回旋加速器固体靶材生产的68 Ga的生产能力,而不是发电机生产的和液体溶液靶材。