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Borosilicate glass 60Co high dose rate brachytherapy thermoluminescence dosimetry
Applied Radiation and Isotopes ( IF 1.6 ) Pub Date : 2021-06-12 , DOI: 10.1016/j.apradiso.2021.109814
A A Z Ahmad Nazeri 1 , S F Abdul Sani 1 , N M Ung 2 , K S Almugren 3 , F H Alkallas 3 , D A Bradley 4
Affiliation  

Brachytherapy is commonly used in treatment of cervical, prostate, breast and skin cancers, also for oral cancers, typically via the application of sealed radioactive sources that are inserted within or alongside the area to be treated. A particular aim of the various brachytherapy techniques is to accurately transfer to the targeted tumour the largest possible dose, at the same time minimizing dose to the surrounding normal tissue, including organs at risk. The dose fall-off with distance from the sources is steep, the dose gradient representing a prime factor in determining the dose distribution, also representing a challenge to the conduct of measurements around sources. Amorphous borosilicate glass (B2O3) in the form of microscope cover slips is recognized to offer a practicable system for such thermoluminescence dosimetry (TLD), providing for high-spatial resolution (down to < 1 mm), wide dynamic dose range, good reproducibility and reusability, minimal fading, resistance to water and low cost. Herein, investigation is made of the proposed dosimeter using a 1.25 MeV High Dose Rate (HDR) 60Co brachytherapy source, characterizing dose response, sensitivity, linearity index and fading. Analysis of the TL glow curves were obtained using the Tmax-Tstop method and first-order kinetics using GlowFit software, detailing the frequency factors and activation energy.



中文翻译:

硼硅酸盐玻璃 60Co 高剂量率近距离放射治疗热释光剂量学

近距离放射疗法通常用于治疗宫颈癌、前列腺癌、乳腺癌和皮肤癌,也用于治疗口腔癌,通常是通过使用插入待治疗区域内或旁边的密封放射源。各种近距离放射治疗技术的一个特定目标是准确地将尽可能大的剂量转移到目标肿瘤,同时最大限度地减少对周围正常组织(包括处于危险中的器官)的剂量。剂量随与源的距离而急剧下降,剂量梯度代表了确定剂量分布的主要因素,也代表了对源周围测量的挑战。无定形硼硅酸盐玻璃(B 2 O 3) 以显微镜盖玻片的形式被认为为这种热释光剂量测定 (TLD) 提供了一个实用的系统,提供高空间分辨率(低至 < 1 mm)、宽动态剂量范围、良好的再现性和可重复使用性、最小的褪色、耐水性和低成本。在此,使用 1.25 MeV 高剂量率 (HDR) 60 Co 近距离放射治疗源对所提议的剂量计进行了研究,对剂量反应、灵敏度、线性指数和衰减进行了表征。使用 T max -T stop方法和使用 GlowFit 软件的一级动力学分析 TL 辉光曲线,详细说明了频率因子和活化能。

更新日期:2021-06-25
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