Interleukin-10 (IL-10) gene polymorphisms have been associated with severity and outcomes in patients with respiratory and nonrespiratory viral infections. The aim of this study was to assess whether rs1800871 and rs1800872 polymorphisms of IL-10 gene are associated with the clinical outcomes of COVID-19 in a Mexican population. Study subjects were 193 COVID-19 patients. The genotyping was carried out with real-time PCR and serum IL-10 levels were measured with enzyme-linked immunosorbent assay. Logistic regression analysis was used for analysis association with clinical outcomes. There was no evidence of an association between alleles, genotypes, or haplotypes frequencies between patient groups according to severity and outcomes. The rs1800871 and rs1800872 polymorphisms might not be genetic risk factors for severity and mortality for COVID-19 in Mexican mestizos patients from northwest Mexico.

中文翻译：

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白细胞介素 10 基因多态性对 COVID-19 临床结果的影响不足

白细胞介素 10 ( IL-10 ) 基因多态性与呼吸道和非呼吸道病毒感染患者的严重程度和预后相关。本研究的目的是评估IL-10 的rs1800871 和 rs1800872 多态性是否基因与墨西哥人群中 COVID-19 的临床结果相关。研究对象是 193 名 COVID-19 患者。基因分型通过实时 PCR 进行，血清 IL-10 水平通过酶联免疫吸附测定进行测量。Logistic回归分析用于分析与临床结果的关联。根据严重程度和结果，没有证据表明患者组之间的等位基因、基因型或单倍型频率之间存在关联。在来自墨西哥西北部的墨西哥混血儿患者中，rs1800871 和 rs1800872 多态性可能不是 COVID-19 严重程度和死亡率的遗传危险因素。