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Combination of a SARS-CoV-2 IgG Assay and RT-PCR for Improved COVID-19 Diagnosis.
Annals of Laboratory Medicine ( IF 4.0 ) Pub Date : 2021-6-11 , DOI: 10.3343/alm.2021.41.6.568
Kotaro Aoki 1 , Kunitomo Takai 2 , Tatsuya Nagasawa 1 , Katsuhito Kashiwagi 3 , Nobuaki Mori 4 , Keiji Matsubayashi 5 , Masahiro Satake 5 , Ippei Tanaka 2 , Nanae Kodama 6 , Takahiro Shimodaira 6 , Yoshikazu Ishii 1 , Taito Miyazaki 3 , Toshiaki Ishii 6 , Toshisuke Morita 7 , Toru Yoshimura 2 , Kazuhiro Tateda 1
Affiliation  

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is generally diagnosed by reverse transcription (RT)-PCR or serological assays. The SARS-CoV-2 viral load decreases a few days after symptom onset. Thus, the RT-PCR sensitivity peaks at three days after symptom onset (approximately 80%). We evaluated the performance of the ARCHITECT® SARS-CoV-2 IgG assay (henceforth termed IgG assay; Abbott Laboratories, Lake County, IL, USA), and the combination of RT-PCR and the IgG assay for COVID-19 diagnosis.

中文翻译:

SARS-CoV-2 IgG 检测和 RT-PCR 相结合以改进 COVID-19 诊断。

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 通常通过逆转录 (RT)-PCR 或血清学检测进行诊断。SARS-CoV-2 病毒载量在症状出现几天后下降。因此,RT-PCR 灵敏度在症状出现后三天达到峰值(约 80%)。我们评估了 ARCHITECT ® SARS-CoV-2 IgG 检测(以下称为 IgG 检测;雅培实验室,伊利诺伊州莱克县,美国)的性能,以及 RT-PCR 和 IgG 检测的组合用于 COVID-19 诊断。
更新日期:2021-06-16
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