Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is generally diagnosed by reverse transcription (RT)-PCR or serological assays. The SARS-CoV-2 viral load decreases a few days after symptom onset. Thus, the RT-PCR sensitivity peaks at three days after symptom onset (approximately 80%). We evaluated the performance of the ARCHITECT^® SARS-CoV-2 IgG assay (henceforth termed IgG assay; Abbott Laboratories, Lake County, IL, USA), and the combination of RT-PCR and the IgG assay for COVID-19 diagnosis.

中文翻译：

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SARS-CoV-2 IgG 检测和 RT-PCR 相结合以改进 COVID-19 诊断。

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 通常通过逆转录 (RT)-PCR 或血清学检测进行诊断。SARS-CoV-2 病毒载量在症状出现几天后下降。因此，RT-PCR 灵敏度在症状出现后三天达到峰值（约 80%）。我们评估了 ARCHITECT ^® SARS-CoV-2 IgG 检测（以下称为 IgG 检测；雅培实验室，伊利诺伊州莱克县，美国）的性能，以及 RT-PCR 和 IgG 检测的组合用于 COVID-19 诊断。