Integrins, including the α and β subunits, are cell adhesion factors that promote intercellular and extracellular matrix (ECM) interactions. Integrin β1 (ITGβ1) is widely expressed in vivo. In addition, ITGβ1 has been shown to promote virus entry into the body. Currently, common carp is severely affected by herpesvirus in the aquaculture industry. However, ITGβ1 in common carp has not yet been identified. In this study, we cloned the full-length cDNA of CcITGβ1 from common carp, which has an open reading frame (ORF) of 2394 bp and encodes a polypeptide of 797 amino acids, with a predicted molecular mass of 88.42 kDa and a theoretical PI of 6.018. Structural features of CcITGβ1 were predicted by biological analysis software. Phylogenetic analysis showed that CcITGβ1 of common carp was highly evolutionarily conserved and clustered with zebrafish ITGβ1α. CcITGβ1 was found to be widely expressed in ten sampled tissues, with highest expression in the intestine. In fish selected to resist cyprinid herpesvirus 3 (CyHV-3), expression of CcITGβ1 was significantly lower than that in control fish at different infection stages, especially the early infection stage. Thus, expression of CcITGβ1 in common carp might play an important role in different stages of CyHV-3 infection, but further studies are required to verify this role.

整联蛋白，包括 α 和 β 亚基，是促进细胞间和细胞外基质 (ECM) 相互作用的细胞粘附因子。整合素β1（ITGβ1）在体内广泛表达。此外，ITGβ1已被证明可促进病毒进入体内。目前，鲤鱼在水产养殖业受到疱疹病毒的严重影响。然而，尚未发现鲤鱼中的ITGβ1。在本研究中，我们克隆了鲤鱼CcITGβ1的全长 cDNA ，其开放阅读框 (ORF) 为 2394 bp，编码 797 个氨基酸的多肽，预测分子量为 88.42 kDa，理论 PI 6.018。CcITGβ1的结构特征由生物分析软件预测。系统发育分析表明，鲤鱼CcITGβ1在进化上高度保守，与斑马鱼ITGβ1α聚类。发现CcITGβ1在十个取样组织中广泛表达，在肠道中表达最高。在选择抵抗鲤类疱疹病毒 3 (CyHV-3) 的鱼中，CcITGβ1 的表达在不同感染阶段，尤其是感染早期阶段显着低于对照鱼。因此，鲤鱼中CcITGβ1 的表达可能在 CyHV-3 感染的不同阶段发挥重要作用，但需要进一步研究来验证这一作用。