当前位置: X-MOL 学术Int. J. Immunopathol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Analysis of allergen profile in patients sensitized to canine allergen and potential Can f 5 cross-reactivity with human PSA
International Journal of Immunopathology and Pharmacology ( IF 3.5 ) Pub Date : 2021-06-11 , DOI: 10.1177/20587384211023670
Natalia Ukleja-Sokołowska 1 , Kinga Lis 1 , Magdalena Żbikowska-Gotz 1 , Rafał Adamczak 2 , Zbigniew Bartuzi 1
Affiliation  

Can f 5 allergy and possible cross-reactivity with human semen in which there are significant amounts of prostate-specific antigen (PSA) are particularly interesting aspects of allergy to dog. The objective of the study was to confirm cross-reactivity between human PSA and Can f 5 in a study of canine sensitised women. A total of 100 women (aged 18–73, 41 on average) with a positive history of animal fur allergy or positive skin prick tests to canine allergens were selected. Levels of Immunoglobulin E (IgE) specific to Can f 1, Can f 2, Can f 3, Can f 5 were determined. Patients with increased concentration of sIgE Can f 5 were selected for further inhibition testing using polystyrene microplate ELISA test coated with human PSA. In the studied population, allergy to Can f 5 dominated (52.3% of patients with increased concentration of canine-specific IgE were allergic to this allergenic component). In all analyzed cases, the concentration of IgE Can f 5 decreased after incubation on the ELISA plate coated with human PSA. The minimum decrease in concentration was 10.44%, the maximum was 37.73%, the average decrease was 21.6%. No statistically significant influence of the presence or absence of allergenic sIgE Can f 5 in blood serum on the occurrence of symptoms after intercourse was found. The study confirmed the moderate ability of Can f 5 to cross-react with human PSA sIgE, which may be clinically significant in some women. At the same time, symptoms of an allergy to male semen do not constitute a typical clinical presentation of allergy to Can f 5.



中文翻译:

对犬过敏原敏感的患者的过敏原谱分析和潜在的 Can f 5 与人类 PSA 的交叉反应

Can f 5 过敏和可能与人精液中存在大量前列腺特异性抗原 (PSA) 的交叉反应是对狗过敏的特别有趣的方面。该研究的目的是确认人类 PSA 和 Can f 5 在对犬类敏感女性的研究中的交叉反应性。共选择了 100 名女性(年龄 18-73 岁,平均 41 岁),这些女性有动物毛皮过敏史或对犬类过敏原的皮肤点刺试验阳性。确定了对 Can f 1、Can f 2、Can f 3、Can f 5 特异性的免疫球蛋白 E (IgE) 水平。选择 sIgE Can f 5 浓度增加的患者进行进一步的抑制测试,使用涂有人 PSA 的聚苯乙烯微孔板 ELISA 测试。在研究人群中,对 Can f 5 的过敏占主导地位 (52. 3% 的犬特异性 IgE 浓度增加的患者对这种过敏原成分过敏)。在所有分析的情况下,在用人 PSA 包被的 ELISA 板上孵育后,IgE Can f 5 的浓度降低。浓度最低下降10.44%,最高37.73%,平均下降21.6%。血清中是否存在致敏性 sIgE Can f 5 对性交后症状的发生没有统计学意义的影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力,这在某些女性中可能具有临床意义。同时,对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。在涂有人PSA的ELISA板上孵育后,IgE Can f 5 的浓度降低。浓度最低下降10.44%,最高37.73%,平均下降21.6%。血清中是否存在致敏性 sIgE Can f 5 对性交后症状的发生没有统计学意义的影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力,这在某些女性中可能具有临床意义。同时,对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。在涂有人PSA的ELISA板上孵育后,IgE Can f 5 的浓度降低。浓度最低下降10.44%,最高37.73%,平均下降21.6%。血清中是否存在致敏性 sIgE Can f 5 对性交后症状的发生没有统计学意义的影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力,这在某些女性中可能具有临床意义。同时,对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。血清中是否存在致敏性 sIgE Can f 5 对性交后症状的发生没有统计学意义的影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力,这在某些女性中可能具有临床意义。同时,对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。血清中是否存在致敏性 sIgE Can f 5 对性交后症状的发生没有统计学意义的影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力,这在某些女性中可能具有临床意义。同时,对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。

更新日期:2021-06-13
down
wechat
bug