Can f 5 allergy and possible cross-reactivity with human semen in which there are significant amounts of prostate-specific antigen (PSA) are particularly interesting aspects of allergy to dog. The objective of the study was to confirm cross-reactivity between human PSA and Can f 5 in a study of canine sensitised women. A total of 100 women (aged 18–73, 41 on average) with a positive history of animal fur allergy or positive skin prick tests to canine allergens were selected. Levels of Immunoglobulin E (IgE) specific to Can f 1, Can f 2, Can f 3, Can f 5 were determined. Patients with increased concentration of sIgE Can f 5 were selected for further inhibition testing using polystyrene microplate ELISA test coated with human PSA. In the studied population, allergy to Can f 5 dominated (52.3% of patients with increased concentration of canine-specific IgE were allergic to this allergenic component). In all analyzed cases, the concentration of IgE Can f 5 decreased after incubation on the ELISA plate coated with human PSA. The minimum decrease in concentration was 10.44%, the maximum was 37.73%, the average decrease was 21.6%. No statistically significant influence of the presence or absence of allergenic sIgE Can f 5 in blood serum on the occurrence of symptoms after intercourse was found. The study confirmed the moderate ability of Can f 5 to cross-react with human PSA sIgE, which may be clinically significant in some women. At the same time, symptoms of an allergy to male semen do not constitute a typical clinical presentation of allergy to Can f 5.

Can f 5 过敏以及可能与含有大量前列腺特异性抗原 (PSA) 的人类精液发生交叉反应是对狗过敏的特别有趣的方面。该研究的目的是在对犬类过敏的女性进行的研究中确认人类 PSA 和 Can f 5 之间的交叉反应性。总共选择了 100 名具有动物毛皮过敏史或对犬过敏原皮肤点刺试验呈阳性的女性（年龄 18-73 岁，平均 41 岁）。测定了 Can f 1、Can f 2、Can f 3、Can f 5 特异性免疫球蛋白 E (IgE) 的水平。选择sIgE Can f 5 浓度增加的患者，使用涂有人PSA的聚苯乙烯微孔板ELISA测试进行进一步的抑制测试。在研究人群中，对 Can f 5 过敏占主导地位（犬特异性 IgE 浓度升高的患者中有 52.3% 对这种过敏成分过敏）。在所有分析的情况下，在涂有人 PSA 的 ELISA 板上孵育后，IgE Can f 5 的浓度下降。浓度下降幅度最小为10.44%，最大为37.73%，平均下降为21.6%。血清中是否存在致敏性sIgE Can f 5 对性交后症状的发生没有统计学上的显着影响。该研究证实了 Can f 5 与人类 PSA sIgE 交叉反应的中等能力，这对于某些女性可能具有临床意义。同时，对男性精液过敏的症状并不构成对 Can f 5 过敏的典型临床表现。