Since its first description in 1979, the hyperpolarization-activated funny current (I_f) has been the object of intensive research aimed at understanding its role in cardiac pacemaker activity and its modulation by the sympathetic and parasympathetic branches of the autonomic nervous system. I_f was described in isolated tissue strips of the rabbit sinoatrial node using the double-electrode voltage-clamp technique. Since then, the rabbit has been the principal animal model for studying pacemaker activity and I_f for more than 20 years. In 2001, the first study describing the electrophysiological properties of mouse sinoatrial pacemaker myocytes and those of I_f was published. It was soon followed by the description of murine myocytes of the atrioventricular node and the Purkinje fibres. The sinoatrial node of genetically modified mice has become a very popular model for studying the mechanisms of cardiac pacemaker activity. This field of research benefits from the impressive advancement of in-vivo exploration techniques of physiological parameters, imaging, genetics, and large-scale genomic approaches. The present review discusses the influence of mouse genetic on the most recent knowledge of the funny current's role in the physiology and pathophysiology of cardiac pacemaker activity. Genetically modified mice have provided important insights into the role of I_f in determining intrinsic automaticity in vivo and in myocytes of the conduction system. In addition, gene targeting of f-(HCN) channel isoforms have contributed to elucidating the current's role in the regulation of heart rate by the parasympathetic nervous system. This review is dedicated to Dario DiFrancesco on his retirement.

自 1979 年首次描述超极化激活的_{滑稽电流 (If} )以来，它一直是深入研究的对象，旨在了解其在心脏起搏器活动中的作用及其对自主神经系统的交感神经和副交感神经分支的调节。使用双电极电压钳技术在兔窦房结的分离组织条中描述了I _{f 。}从那时起，兔子一直是研究起搏器活动的主要动物模型，₂₀多年来。2001 年，第一项描述小鼠窦房起搏器肌细胞和I _{f的电生理特性的研究}发表了。紧随其后的是房室结和浦肯野纤维的小鼠肌细胞的描述。转基因小鼠的窦房结已成为研究心脏起搏器活动机制的一种非常流行的模型。这一研究领域受益于生理参数、成像、遗传学和大规模基因组方法的体内探索技术的显着进步。本综述讨论了小鼠遗传对最新知识的影响，即滑稽电流在心脏起搏器活动的生理学和病理生理学中的作用。转基因小鼠为I _f在确定体内内在自动性中的作用提供了重要见解在传导系统的肌细胞中。此外，f-(HCN) 通道亚型的基因靶向有助于阐明电流在副交感神经系统调节心率中的作用。这篇评论是献给达里奥·迪弗朗西斯科（Dario DiFrancesco）退休的。