Abstract

It is known that the alpha isoform of heat shock protein 90 (HSP90α) plays an important role in wound healing. HSP90α has a stimulating effect on migration and invasion of cells in the wound area. The role of beta isoform of HSP90 (HSP90β) in wound healing has not been fully determined. Recombinant human HSP90β expressed in E. coli has been obtained and characterized in the present work. By using an excision model of wound healing in mice, it was shown that purified recombinant human HSP90β introduced into the wound area increases the rate of wound healing by 28% compared to the control. This fact allows HSP90β to be considered a promising drug for wound healing.

中文翻译：

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重组热休克蛋白90β（HSP90β）对小鼠伤口愈合率的影响

摘要

众所周知，热休克蛋白 90 (HSP90α) 的 α 亚型在伤口愈合中起着重要作用。HSP90α对伤口区域细胞的迁移和侵袭有刺激作用。HSP90 的 β 亚型（HSP90β）在伤口愈合中的作用尚未完全确定。在目前的工作中已经获得并表征了在大肠杆菌中表达的重组人 HSP90β 。通过使用小鼠伤口愈合的切除模型，结果表明，与对照相比，引入伤口区域的纯化重组人 HSP90β 使伤口愈合率提高了 28%。这一事实使 HSP90β 被认为是一种有前途的伤口愈合药物。