Abstract Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments for serious diseases, including severe infections. Planning and conducting investigator-initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary Pseudomonas aeruginosa infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.

中文翻译：

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慢性和复发性铜绿假单胞菌肺部感染的动物模型：大环内酯治疗的意义

摘要：人类疾病的动物模型是识别和测试包括严重感染在内的严重疾病的新疗法的宝贵且不可避免的元素。计划和进行由研究者发起的人体试验通常被认为具有极大的挑战性。相比之下，建立相关传染病动物模型需要多少计划，包括背景和修改实验，往往被低估了。然而，具有代表性的动物感染模型，经过精心设计以测试生成的假设，有助于提高我们对发病机制、毒力因子和宿主反应的理解，并确定新的治疗候选者和治疗策略。如果合适，这些结果可以随后进行临床测试。本综述旨在介绍所有肺介绍了我们所了解的铜绿假单胞菌感染模型以及我们实验室中已建立的动物模型的详细描述，重点是大环内酯类药物治疗。