The reported incidence of pertussis in European countries varies considerably. We aimed to study specific Bordetella pertussis seroprevalence in Europe by measuring serum IgG antibody levels to pertussis toxin (anti-PT IgG). Fourteen national laboratories participated in this study including Belgium, Denmark, Finland, Greece, Hungary, Italy, Lithuania, Malta, Norway, Poland, Portugal, Romania, Spain, and Sweden. Each country collected approximately 250 samples (N = 7903) from the age groups 20–29 years (N = 3976) and 30–39 years (N = 3927) during 2010–2013. Samples were anonymous residual sera from diagnostic laboratories and were analyzed at the national laboratories by a Swedish reference method, a commercial ELISA kit, or were sent to Sweden for analysis. The median anti-PT IgG concentrations ranged from 4 to 13.6 IU/mL. The proportion of samples with anti-PT IgG ≥100 IU/mL, indicating a recent infection ranged from 0.2% (Hungary) to 5.7% (Portugal). The highest proportion of sera with anti-PT IgG levels between 50 and <100 IU/mL, indicating an infection within the last few years, was found in Portugal (12.3%) and Italy (13.9%). This study shows that the circulation of B. pertussis is quite extensive in adults, aged 20–39 years, despite well-established vaccination programs in Europe.

中文翻译：

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14 个欧洲国家育龄成人（20-39 岁）百日咳血清阳性率

欧洲国家报告的百日咳发病率差异很大。我们旨在研究特定的百日咳博德特氏菌通过测量百日咳毒素（抗 PT IgG）的血清 IgG 抗体水平来确定欧洲的血清阳性率。包括比利时、丹麦、芬兰、希腊、匈牙利、意大利、立陶宛、马耳他、挪威、波兰、葡萄牙、罗马尼亚、西班牙和瑞典在内的 14 个国家实验室参与了这项研究。每个国家在 2010-2013 年期间从 20-29 岁（N = 3976）和 30-39 岁（N = 3927）年龄组中收集了大约 250 个样本（N = 7903）。样本是来自诊断实验室的匿名残留血清，并在国家实验室通过瑞典参考方法、商业 ELISA 试剂盒进行分析，或送往瑞典进行分析。中值抗 PT IgG 浓度范围为 4 至 13.6 IU/mL。抗 PT IgG ≥100 IU/mL 的样本比例，表明近期感染范围从 0.2%（匈牙利）到 5.7%（葡萄牙）。在葡萄牙 (12.3%) 和意大利 (13.9%) 发现了最高比例的血清中抗 PT IgG 水平介于 50 和 <100 IU/mL 之间，表明在过去几年内发生过感染。本研究表明，循环尽管欧洲有完善的疫苗接种计划，但百日咳杆菌在 20-39 岁的成年人中非常普遍。