Background Prior diagnosis of heart failure (HF) is associated with increased length of hospital stay (LOS) and mortality from COVID-19. Associations between substance use, venous thromboembolism (VTE) or peripheral arterial disease (PAD) and its effects on LOS or mortality in patients with HF hospitalised with COVID-19 remain unknown. Objective This study identified risk factors associated with poor in-hospital outcomes among patients with HF hospitalised with COVID-19. Methods Case–control study was conducted of patients with prior diagnosis of HF hospitalised with COVID-19 at an academic tertiary care centre from 1 January 2020 to 28 February 2021. Patients with HF hospitalised with COVID-19 with risk factors were compared with those without risk factors for clinical characteristics, LOS and mortality. Multivariate regression was conducted to identify multiple predictors of increased LOS and in-hospital mortality in patients with HF hospitalised with COVID-19. Results Total of 211 patients with HF were hospitalised with COVID-19. Women had longer LOS than men (9 days vs 7 days; p<0.001). Compared with patients without PAD or ischaemic stroke, patients with PAD or ischaemic stroke had longer LOS (7 days vs 9 days; p=0.012 and 7 days vs 11 days, p<0.001, respectively). Older patients (aged 65 and above) had increased in-hospital mortality compared with younger patients (adjusted OR: 1.04; 95% CI 1.00 to 1.07; p=0.036). Prior diagnosis of VTE increased mortality more than threefold in patients with HF hospitalised with COVID-19 (adjusted OR: 3.33; 95% CI 1.29 to 8.43; p=0.011). Conclusion Vascular diseases increase LOS and mortality in patients with HF hospitalised with COVID-19. All data relevant to the study are included in the article or uploaded as supplemental information. Others can reuse and share our data with others as long as they credit and cite us, but not for commercial uses.

中文翻译：

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血管合并症使因 COVID-19 住院的心力衰竭患者的预后恶化

背景 心力衰竭 (HF) 的先前诊断与 COVID-19 引起的住院时间 (LOS) 和死亡率增加有关。物质使用、静脉血栓栓塞 (VTE) 或外周动脉疾病 (PAD) 及其对因 COVID-19 住院的 HF 患者的 LOS 或死亡率的影响之间的关联仍然未知。目的 本研究确定了与 COVID-19 住院的 HF 患者住院结果不佳相关的危险因素。方法 对 2020 年 1 月 1 日至 2021 年 2 月 28 日在学术三级医疗中心因 COVID-19 住院的既往诊断为 HF 的 HF 患者进行病例对照研究。临床特征、LOS 和死亡率的危险因素。进行多变量回归以确定因 COVID-19 住院的 HF 患者 LOS 和院内死亡率增加的多个预测因素。结果 共有 211 名 HF 患者因 COVID-19 住院。女性的 LOS 比男性长（9 天 vs 7 天；p<0.001）。与没有 PAD 或缺血性卒中的患者相比，有 PAD 或缺血性卒中的患者的 LOS 更长（7 天 vs 9 天；分别为 p=0.012 和 7 天 vs 11 天，p<0.001）。与年轻患者相比，老年患者（65 岁及以上）的住院死亡率增加（调整后的 OR：1.04；95% CI 1.00 至 1.07；p=0.036）。在因 COVID-19 住院的 HF 患者中，先前诊断为 VTE 的死亡率增加了三倍以上（调整后的 OR：3.33；95% CI 1.29 至 8.43；p=0.011）。结论 血管疾病会增加因 COVID-19 住院的 HF 患者的 LOS 和死亡率。与研究相关的所有数据都包含在文章中或作为补充信息上传。其他人可以重复使用并与他人共享我们的数据，只要他们信任和引用我们，但不能用于商业用途。