Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anatomic distribution of localized drug delivery for these organs using existing therapeutic modalities is limited. Application of local depots in a circumferential and extended longitudinal fashion could transform our capacity to offer effective treatment across a range of conditions. Here we report the development and application of a kirigami-based stent platform to achieve this. The stents comprise a stretchable snake-skin-inspired kirigami shell integrated with a fluidically driven linear soft actuator. They have the capacity to deposit drug depots circumferentially and longitudinally in the tubular mucosa of the gastrointestinal tract across millimetre to multi-centimetre length scales, as well as in the vasculature and large airways. We characterize the mechanics of kirigami stents for injection, and their capacity to engage tissue in a controlled manner and deposit degradable microparticles loaded with therapeutics by evaluating these systems ex vivo and in vivo in swine. We anticipate such systems could be applied for a range of endoluminal diseases by simplifying dosing regimens while maximizing drug on-target effects through the sustained release of therapeutics and minimizing systemic side effects.

植入式药物仓库能够通过最大限度地提高局部药物疗效并最大限度地减少潜在的全身副作用来局部满足治疗要求。包括胃肠道、呼吸道和脉管系统在内的管状器官均表现为腔内疾病。使用现有治疗方式对这些器官进行局部药物递送的解剖学分布是有限的。以圆周和纵向延伸的方式应用局部储存库可以改变我们在各种条件下提供有效治疗的能力。在这里，我们报告了基于剪纸的支架平台的开发和应用来实现这一目标。该支架包括一个可拉伸的蛇皮剪纸外壳，与流体驱动的线性软致动器集成。它们能够在毫米至多厘米长度尺度的胃肠道管状粘膜以及脉管系统和大气道中沿周向和纵向沉积药物储库。我们通过在猪体内和离体评估这些系统来表征注射用剪纸支架的力学特征，以及它们以受控方式接合组织并沉积负载治疗剂的可降解微粒的能力。我们预计此类系统可以通过简化给药方案来应用于一系列腔内疾病，同时通过治疗药物的持续释放来最大化药物的靶向效果并最小化全身副作用。