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Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma
Pediatric Blood & Cancer ( IF 2.4 ) Pub Date : 2021-06-14 , DOI: 10.1002/pbc.29172
Richard T Graham 1, 2, 3 , Mohammad H Abu-Arja 2, 4 , Joseph R Stanek 5 , Andrea Cappellano 6 , Christina Coleman 7 , Susan Chi 8 , Tabitha Cooney 8 , Girish Dhall 9 , Jacob G Ellen 10 , Jonathan L Finlay 2 , Michael J Fisher 10 , Gregory K Friedman 9 , Amar Gajjar 3 , Karen Gauvain 11 , Lindsey M Hoffman 12 , Juliette Hukin 13 , John T Lucas 14 , Sabine Mueller 7 , Pournima Navalkele 15 , Rebecca Ronsley 13 , Christopher Tinkle 14 , Stephanie Villeneuve 16 , Kee Kiat Yeo 8 , Jack M Su 17 , Ashley Margol 18 , Nicholas G Gottardo 19 , Jeffrey Allen 20 , Roger Packer 21 , Ute Bartels 22 , Mohamed S Abdelbaki 2, 11
Affiliation  

Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat given their rarity and poorly defined imaging characteristics. Craniospinal (CSI), whole brain (WBI), whole ventricle (WVI), and focal RT have all been utilized; however, the best treatment strategy remains unclear.

中文翻译:

基底节和丘脑生殖细胞瘤治疗方式的多机构分析

中枢神经系统 (CNS) 生殖细胞瘤是治疗敏感的肿瘤,具有良好的生存结果。目前的治疗策略将化疗与放疗 (RT) 相结合,以减少放疗的野和剂量。起源于基底神经节/丘脑 (BGTG) 的生殖细胞瘤已被证明具有挑战性,因为它们罕见且影像学特征不明确。颅脊髓 (CSI)、全脑 (WBI)、全脑室 (WVI) 和局灶性放疗均已使用;然而,最佳治疗策略仍不清楚。
更新日期:2021-08-23
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