Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma,Pediatric Blood & Cancer

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Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma
Pediatric Blood & Cancer ( IF 2.4 ) Pub Date : 2021-06-14 , DOI: 10.1002/pbc.29172
Richard T Graham _{1,

2,

3} , Mohammad H Abu-Arja _{2,

4} , Joseph R Stanek ₅ , Andrea Cappellano ₆ , Christina Coleman ₇ , Susan Chi ₈ , Tabitha Cooney ₈ , Girish Dhall ₉ , Jacob G Ellen ₁₀ , Jonathan L Finlay ₂ , Michael J Fisher ₁₀ , Gregory K Friedman ₉ , Amar Gajjar ₃ , Karen Gauvain ₁₁ , Lindsey M Hoffman ₁₂ , Juliette Hukin ₁₃ , John T Lucas ₁₄ , Sabine Mueller ₇ , Pournima Navalkele ₁₅ , Rebecca Ronsley ₁₃ , Christopher Tinkle ₁₄ , Stephanie Villeneuve ₁₆ , Kee Kiat Yeo ₈ , Jack M Su ₁₇ , Ashley Margol ₁₈ , Nicholas G Gottardo ₁₉ , Jeffrey Allen ₂₀ , Roger Packer ₂₁ , Ute Bartels ₂₂ , Mohamed S Abdelbaki _{2,

11}

Affiliation

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Pediatrics, New York-Presbyterian Brooklyn Methodist Hospital, Weill-Cornell College of Medicine, Brooklyn, New York, USA.
Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio, USA.
Instituto de Oncologia Pediátrica GRAACC/UNIFESP, Division of Neuroncology, Sao Paulo, Brazil.
Departments of Pediatrics, Neurology, and Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
Dana Farber/Boston Children's Cancer and Blood Disorder Center, Pediatric Neuro-Oncology, Boston, Massachusetts, USA.
Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.
Division of Hematology/Oncology, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Division of Hematology and Oncology, Children's and Women's Health Centre of B.C., University of British Columbia, Vancouver, British Columbia, Canada.
Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Pediatrics, SSM Cardinal Glennon Children's Hospital, Saint Louis University, Saint Louis, Missouri, USA.
Division of Hematology/Oncology, Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia, Canada.
Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.
Cancer and Blood Disease Institute and Division of Hematology-Oncology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Department of Pediatrics, NYU Langone Health, New York, New York, USA.
Center for Neuroscience and Behavioral Medicine, Brain Tumor Institute, Children's National Health System, Washington, District of Columbia, USA.
Division of Hematology/Oncology, Pediatric Neuro-Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat given their rarity and poorly defined imaging characteristics. Craniospinal (CSI), whole brain (WBI), whole ventricle (WVI), and focal RT have all been utilized; however, the best treatment strategy remains unclear.

中文翻译：

基底节和丘脑生殖细胞瘤治疗方式的多机构分析

中枢神经系统 (CNS) 生殖细胞瘤是治疗敏感的肿瘤，具有良好的生存结果。目前的治疗策略将化疗与放疗 (RT) 相结合，以减少放疗的野和剂量。起源于基底神经节/丘脑 (BGTG) 的生殖细胞瘤已被证明具有挑战性，因为它们罕见且影像学特征不明确。颅脊髓 (CSI)、全脑 (WBI)、全脑室 (WVI) 和局灶性放疗均已使用；然而，最佳治疗策略仍不清楚。

更新日期：2021-08-23

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