The present report describes the motivation for the Michigan Twin Neurogenetic Study (MTwiNS), which seeks to illuminate the underlying biological mechanisms through which familial and community factors support resilience (i.e., adaptive competence in the face of adversity) in youth exposed to neighborhood disadvantage. To accomplish these goals, we must first understand how resilience manifests in this cohort. The current study uncovers evidence of three domains of youth resilience: psychiatric health, social engagement, and scholastic success. Although all three domains were relatively stable across a one-to-two year period, some change was observed. Additionally, although resilience in one domain was quite common, resilience across all three domains was less common. Finally, we show substantial variability in resilience within and across families, with large co-twin discordances that can be leveraged in future analyses that examine promotive contexts that are environmental in origin.

本报告描述了密歇根双胞胎神经遗传学研究 (MTwiNS) 的动机，该研究旨在阐明家庭和社区因素支持处于邻里不利地位的青年的复原力（即，面对逆境时的适应能力）的潜在生物学机制。为了实现这些目标，我们必须首先了解韧性在这个群体中的表现。目前的研究揭示了青少年复原力的三个领域的证据：精神健康、社会参与和学业成功。尽管所有三个领域在一到两年的时间里都相对稳定，但观察到了一些变化。此外，尽管一个领域的弹性相当普遍，但所有三个领域的弹性都不太常见。最后，