ABSTRACT

Cognitive problems are common in people with Multiple Sclerosis (MS), and researchers and clinicians have used a vast array of measures to assess cognition. Our aim was to systematically identify cognitive measures routinely used in MS research, and outline their different uses. Previous recommendations of cognitive measures to use in MS have relied on expert consensus approaches. We believe this systematic review is a starting point for an evidence-based approach to recommend cognitive tests for use with people with MS. We systematically searched electronic databases using relevant search terms for studies that assessed cognitive functioning in MS (last search in February 2020). From 11,854 abstracts retrieved, based on title and abstract review, 2563 remained. Data were extracted from 1526 studies. Studies used 5665 measures of cognition, with 316,053 people with MS. Substitutional style tests, serial addition tests, and word list learning tests were the most commonly used individual tests, and the Brief Repeatable Battery of Neuropsychological Tests was the most commonly used battery. Some of the most frequently used measures were potentially inappropriate due to measuring irrelevant domains of cognition, and issues with sensitivity. Further research is needed to ascertain the psychometric properties, and acceptability of measures for people with MS.

摘要

认知问题在多发性硬化症 (MS) 患者中很常见，研究人员和临床医生已使用大量措施来评估认知。我们的目标是系统地识别 MS 研究中常规使用的认知测量，并概述它们的不同用途。以前在 MS 中使用认知测量的建议依赖于专家共识方法。我们认为，这项系统评价是基于证据的方法的起点，可以推荐用于 MS 患者的认知测试。我们使用相关搜索词系统地搜索了电子数据库，以查找评估 MS 认知功能的研究（最后一次搜索是在 2020 年 2 月）。根据标题和摘要审查，从检索到的 11,854 份摘要中，剩下 2563 份。从 1526 项研究中提取数据。研究使用了 5665 项认知测量，有 316,053 人患有 MS。替代风格测试、系列添加测试和单词列表学习测试是最常用的个人测试，而神经心理学测试的简短可重复电池是最常用的电池。由于测量不相关的认知领域和敏感性问题，一些最常用的测量方法可能不合适。需要进一步研究以确定 MS 患者的心理测量特性和措施的可接受性。由于测量不相关的认知领域和敏感性问题，一些最常用的测量方法可能不合适。需要进一步研究以确定 MS 患者的心理测量特性和措施的可接受性。由于测量不相关的认知领域和敏感性问题，一些最常用的测量方法可能不合适。需要进一步研究以确定 MS 患者的心理测量特性和措施的可接受性。