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Development of a Quantitative Determination Method for a Benzimidazole Derivative with Laboratory Code RU-31 and Antimigraine Activity in Biological Samples
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2021-06-14 , DOI: 10.1007/s11094-021-02418-9 L. A. Smirnova , A. F. Ryabukha , K. A. Kuznetsov , M. V. Velikopolskaya , A. A. Spasov , D. S. Yakovlev
中文翻译:
实验室代码为 RU-31 的苯并咪唑衍生物和生物样品中抗偏头痛活性的定量测定方法的开发
更新日期:2021-06-14
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2021-06-14 , DOI: 10.1007/s11094-021-02418-9 L. A. Smirnova , A. F. Ryabukha , K. A. Kuznetsov , M. V. Velikopolskaya , A. A. Spasov , D. S. Yakovlev
A quantitative determination method for drug substance RU-31, a derivative of a methoxyphenylimidazo - [1,2-α]benzimidazole possessing antimigraine activity, in biological samples was developed. This method has selectivity and high sensitivity sufficient to allow its use for pharmacokinetic studies of RU-31. The sensitivity of the method (detection limit) for RU-31 is 100 ng/mL; limit of quantitation, 500 ng/mL. The average measurement error is ≤15%.
中文翻译:
实验室代码为 RU-31 的苯并咪唑衍生物和生物样品中抗偏头痛活性的定量测定方法的开发
建立了生物样品中原料药 RU-31(具有抗偏头痛活性的甲氧基苯基咪唑 - [1,2-α] 苯并咪唑衍生物)的定量测定方法。该方法具有选择性和高灵敏度,足以使其用于 RU-31 的药代动力学研究。该方法对 RU-31 的灵敏度(检测限)为 100 ng/mL;定量限,500 ng/mL。平均测量误差≤15%。