In the fight of bacteria with human, bacteria have regained the upper hand by development of antibiotic resistance. The emergence of resistance has outpaced the development of new antibiotics, and investment in research and development of new antibiotics is diminishing, which has caused the world entering into a post-antibiotic era for that minor injuries and common infections can kill human beings in the future. Supramolecular macrocycles, due to their unique structures, facile and versatile functionality, abundant host–guest complexation abilities, and dynamic and modular properties, have been widely explored to fabricate versatile functional materials. In particular, they have been demonstrated as useful platforms for the design of elaborate structures for antibacterial use. In this review, we will briefly present basic concepts, novel strategies, and unique antibacterial activities of different antibacterial materials based on different supramolecular macrocycles, including pillararenes, cucurbiturils, cyclodextrins, calixarenes, crown ethers, and other macrocycles, which may open an alternative way to complement traditional drugs, facilitate the development of modern medicine, and overcome the antibiotic-resistance crisis.

在细菌与人类的斗争中，由于抗生素耐药性的发展，细菌重新占据了上风。耐药性的出现超过了新抗生素的开发，新抗生素的研发投入不断减少，导致世界进入了后抗生素时代，未来轻伤和普通感染可致人于死地。 . 超分子大环由于其独特的结构、简便和多功能的功能、丰富的主客体络合能力以及动态和模块化的特性，已被广泛用于制造多功能功能材料。特别是，它们已被证明是设计用于抗菌用途的精细结构的有用平台。在这篇综述中，我们将简要介绍基本概念，