High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer,Urologic Oncology: Seminars and Original Investigations

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High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer
Urologic Oncology: Seminars and Original Investigations ( IF 2.4 ) Pub Date : 2021-06-14 , DOI: 10.1016/j.urolonc.2021.05.010
Katja Nitschke ₁ , Thomas S Worst ₁ , Sophie Madeleine von Rhade ₁ , Blerta Thaqi ₁ , Manuel Neuberger ₁ , Frederik Wessels ₁ , Cleo-Aron Weis ₂ , Stefan Porubsky ₃ , Timo Gaiser ₂ , Maximilian Kriegmair ₁ , Jost von Hardenberg ₁ , Marc Weidenbusch ₄ , Philipp Erben ₁ , Philipp Nuhn ₁

Affiliation

Background

The cell surface interleukin 22 (IL-22) receptor complex is mainly expressed in epithelial and tissue cells like pancreatitis cells. Recent studies described that IL-22R was overexpressed in malignant diseases and was associated with a poor overall survival (OS). The role of IL-22RA1 gene expression in muscle invasive bladder cancer (MIBC) has not been investigated, yet.

Objectives

The aim of this study was to analyze the role of IL-22RA1 gene expression in patients with MIBC.

Methods

In a cohort of 114 patients with MIBC who underwent radical cystectomy, IL-22RA1 gene expression was analyzed with qRT-PCR and correlated with clinical parameters. Furthermore, Kaplan-Meier and Cox regression analysis were performed. For validation, an in silico dataset (TCGA 2017, n=407) was reanalyzed.

Results

IL-22RA1 gene expression was independent of clinicopathological parameters like age (P=0.2681), T stage (P=0.2130), nodal status (P=0.3238) and lymph vascular invasion (LVI, P=0.5860) in patients with MIBC. A high expression of IL-22RA1 was associated with a shorter OS (P=0.0040) and disease-specific survival (P=0.0385). Furthermore, a shorter disease-free survival (DFS) was also associated with a high expression of IL-22RA1 (P=0.0102). In the multivariable analysis, IL-22RA1 expression was an independent prognostic predictors regarding OS (P=0.0096, HR=0.48). In the TCGA cohort, IL-22RA1 expression was independent regarding to OS and DFS.

Conclusion

A high IL-22RA1 gene expression was associated with worse outcome. Furthermore, IL-22RA1 represented an independent predictor regarding OS in our cohort and therefore might be used for risk stratification in patients with MIBC.

中文翻译：

高 IL-22RA1 基因表达与肌肉浸润性膀胱癌的不良预后相关

背景

细胞表面白细胞介素 22 (IL-22) 受体复合物主要在胰腺炎细胞等上皮细胞和组织细胞中表达。最近的研究描述了IL-22R在恶性疾病中过度表达，并且与较差的总生存率 (OS) 相关。的作用IL-22RA1基因表达在肌层浸润性膀胱癌（MIBC）仍未得到研究，但。

目标

本研究的目的是分析IL-22RA1基因表达在 MIBC 患者中的作用。

方法

在 114 名接受根治性膀胱切除术的 MIBC 患者队列中，用 qRT-PCR 分析了IL-22RA1基因表达并与临床参数相关联。此外，还进行了 Kaplan-Meier 和 Cox 回归分析。为了验证，重新分析了计算机数据集（TCGA 2017，n = 407）。

结果

IL-22RA1基因表达与MIBC患者的临床病理参数如年龄（P = 0.2681）、T分期（P = 0.2130）、淋巴结状态（P = 0.3238）和淋巴管浸润（LVI，P = 0.5860）无关。IL-22RA1 的高表达与较短的 OS ( P = 0.0040) 和疾病特异性存活 ( P = 0.0385) 相关。此外，较短的无病生存期 (DFS) 也与IL-22RA1的高表达有关( P = 0.0102 ) 。在多变量分析中，IL-22RA1表达是 OS 的独立预后预测因子。P = 0.0096，HR = 0.48）。在 TCGA 队列中，IL-22RA1 的表达与 OS 和 DFS 无关。