Abstract

Background

While Opioid use disorder (OUD)-related mortality is epidemic in the United States, regions like Appalachia are disproportionately affected. Moreover, a dual epidemic of Hepatitis C virus (HCV) infections and OUD-related admissions has been observed.

Objective

To evaluate sociodemographic characteristics of opioid-dependent patients admitted for medically managed withdrawal in East Tennessee and compare those with and without HCV.

Methods

Cross-sectional study of patients with an OUD admitted for treatment, comparing those with and without a history of HCV.

Results

The studied population was found to have high rates of HCV (36%), intravenous drug use (IVDU) (77%), polysubstance use (84%), previous incarceration (87%), and unemployment (80%). Patients with HCV, compared to those without, were significantly more likely to have a history of IVDU, IVDU complications, and polysubstance use.

Conclusions

This sample reflects the significant morbidity of OUD in East Tennessee. To prevent mortality, contributing factors such as polysubstance use and OUD treatment during incarceration need to be specifically addressed.

中文翻译：

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田纳西州东部因药物治疗阿片类药物戒断入院的患者与丙型肝炎相关的社会人口学特征

摘要

背景

虽然与阿片类药物使用障碍 (OUD) 相关的死亡率在美国很流行，但阿巴拉契亚等地区受到的影响尤为严重。此外，已经观察到丙型肝炎病毒 (HCV) 感染和 OUD 相关入院的双重流行。

客观的

评估东田纳西州因药物戒断而入院的阿片类药物依赖患者的社会人口学特征，并比较患有和未患有 HCV 的患者。

方法

对接受治疗的 OUD 患者进行横断面研究，比较有和没有 HCV 病史的患者。

结果

研究发现，研究人群的 HCV 感染率（36%）、静脉药物使用（IVDU）（77%）、多种物质使用（84%）、既往监禁（87%）和失业（80%）的比例很高。与没有 HCV 的患者相比，HCV 患者更可能有 IVDU、IVDU 并发症和多种物质使用史。

结论

该样本反映了东田纳西州 OUD 的显着发病率。为了防止死亡，需要特别解决监禁期间使用多种物质和 OUD 治疗等促成因素。