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Unmasking latent thioesters under hydrophobic-compatible conditions
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-06-13 , DOI: 10.1002/psc.3358 Wade S Perkins 1 , Ryan T Davison 1 , Gregory B Shelkey 1 , Vernon E Lawson 1 , Grace E Hutton 1 , Justin S Miller 1
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-06-13 , DOI: 10.1002/psc.3358 Wade S Perkins 1 , Ryan T Davison 1 , Gregory B Shelkey 1 , Vernon E Lawson 1 , Grace E Hutton 1 , Justin S Miller 1
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Hydrophobic latent C-terminal thioesters were converted into thioesters, and were also coupled with cysteine in one-pot reactions, using conditions generally compatible with hydrophobic materials. The reaction conditions (ethanethiol and triethylamine in a mixture of DMF and THF) are compatible with acid-labile protecting groups (Boc/t-Bu) that are standard in Fmoc peptide synthesis.
中文翻译：
在疏水相容条件下揭示潜在的硫酯
疏水性潜在的 C 末端硫酯被转化为硫酯，并且还使用通常与疏水材料相容的条件在一锅反应中与半胱氨酸偶联。反应条件（DMF 和 THF 混合物中的乙硫醇和三乙胺）与 Fmoc 肽合成中的标准酸不稳定保护基团 (Boc/t-Bu) 兼容。
更新日期：2021-06-13
中文翻译：
在疏水相容条件下揭示潜在的硫酯
疏水性潜在的 C 末端硫酯被转化为硫酯，并且还使用通常与疏水材料相容的条件在一锅反应中与半胱氨酸偶联。反应条件（DMF 和 THF 混合物中的乙硫醇和三乙胺）与 Fmoc 肽合成中的标准酸不稳定保护基团 (Boc/t-Bu) 兼容。
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