A novel multikinase inhibitor SKLB-YTH-60 ameliorates inflammation and fibrosis in bleomycin-induced lung fibrosis mouse models,Cell Proliferation

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A novel multikinase inhibitor SKLB-YTH-60 ameliorates inflammation and fibrosis in bleomycin-induced lung fibrosis mouse models
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-06-14 , DOI: 10.1111/cpr.13081
Hongyao Liu ₁ , Xiuli Wu ₁ , Cailing Gan ₁ , Liqun Wang ₂ , Guan Wang ₁ , Lin Yue ₁ , Zhihao Liu ₁ , Wei Wei ₁ , Xingping Su ₁ , Qianyu Zhang ₂ , Zui Tan ₁ , Yuqin Yao ₂ , Liang Ouyang ₁ , Luoting Yu ₁ , Tinghong Ye ₁

Affiliation

Idiopathic pulmonary fibrosis (IPF) is marked by the excessive accumulation of extracellular matrix, which participates in a variety of chronic diseases or injuries and seriously threatens human health. Due to the side effects of clinical drugs, there is still a need to develop novel and less toxic drugs to treat pulmonary fibrosis.

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