Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†,Photochemistry and Photobiology

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Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-06-14 , DOI: 10.1111/php.13467
Chloe B Smith ₁ , Lindsay C Days ₁ , Duaa R Alajroush ₁ , Khadija Faye ₁ , Yara Khodour ₁ , Stephen J Beebe ₂ , Alvin A Holder ₁

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Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitizer and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species such as cytotoxic singlet oxygen (¹O₂) to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient’s body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anticancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

中文翻译：

用于治疗癌症的无机复合物的光动力疗法†

光动力疗法 (PDT) 是一种医疗工具，它使用光敏剂和光源来治疗包括癌症在内的多种疾病。PDT 使用活性氧物质如细胞毒性单线态氧 ( ¹ O ₂ ) 来诱导癌细胞中的细胞死亡。化学疗法历来利用许多金属的细胞毒性作用，尤其是过渡金属络合物。然而，化学疗法是一种全身性治疗，因此患者体内的所有细胞都会受到相同的细胞毒性作用。过渡金属配合物作为 PDT 剂也显示出高细胞毒性。PDT 是一种潜在的局部方法，通过使用无机复合物作为光敏剂来治疗多种癌症类型。这篇综述涵盖了几种体外和体内研究以及临床试验报告了用于 PDT 的无机药物对不同类型癌症的抗癌特性。

更新日期：2021-06-14

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