We have designed and developed an effective drug delivery system using biocompatible polymer of poly (ethylene glycol)-polyaspartic acid (mPEG-PAsp) for co-loading the chemotherapy drugs paclitaxel (PTX) and cisplatin (CP) in one nano-vehicle. This study aimed to improve the anti-cancer efficacy of combinations of chemotherapy drugs and reduce their side effects. mPEG-PAsp-(PTX/Pt) nano-micelles disperse well in aqueous solution and have a narrow size distribution (37.8 ± 3.2 nm) in dynamic light scattering (DLS). Drug release profiles found that CP released at pH 5.5 was significantly faster than that at pH 7.4. MPEG-PAsp-(PTX/Pt) nano-micelles displayed a significantly higher tumor inhibitory effect than mPEG-PAsp-PTX nano-micelles when the polymer concentrations reached 50 μg/mL. Our data indicated that polymer micelles of mPEG-PAsp loaded with the combined drug exert synergistic anti-tumor efficacy on SKOV3 ovarian cells via different action mechanisms. Results from our studies suggested that mPEG-PAsp-(PTX/Pt) nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.

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用于卵巢癌化疗的顺铂和紫杉醇共递送纳米系统

我们设计并开发了一种有效的药物递送系统，该系统使用聚乙二醇-聚天冬氨酸 (mPEG-PAsp) 的生物相容性聚合物将化疗药物紫杉醇 (PTX) 和顺铂 (CP) 共同装载在一个纳米载体中。本研究旨在提高化疗药物组合的抗癌功效并减少其副作用。mPEG-PAsp-(PTX/Pt) 纳米胶束在水溶液中分散良好，在动态光散射 (DLS) 中具有窄的尺寸分布 (37.8 ± 3.2 nm)。药物释放曲线发现，pH 5.5 时 CP 的释放速度明显快于 pH 7.4 时的释放速度。当聚合物浓度达到50 μg/mL时，MPEG-PAsp-(PTX/Pt)纳米胶束显示出比mPEG-PAsp-PTX纳米胶束显着更高的肿瘤抑制作用。我们的数据表明，载有联合药物的 mPEG-PAsp 聚合物胶束通过不同的作用机制对 SKOV3 卵巢细胞发挥协同抗肿瘤作用。我们的研究结果表明，mPEG-PAsp-(PTX/Pt) 纳米胶束是用于携带和改善具有不同水溶性的治疗药物输送的有前景的替代品。