Cerium oxide nanoparticles with integrated gadolinium have been proved to be useful as contrast agents in magnetic resonance imaging. Of question is their performance in dual-energy computed tomography. The aims of this work are to determine (1) the relation between the computed tomography number and the concentration of the I, Gd or Ce contrast agent and (2) under what conditions it is possible to resolve the type of contrast agent. Hounsfield values of iodoacetic acid, gadolinium acetate and cerium acetate dissolved in water at molar concentrations of 10, 50 and 100 mM were measured in a water phantom using the Siemens SOMATOM Definition Force scanner; gadolinium- and cerium acetate were used as substitutes for the gadolinium-integrated cerium oxide nanoparticles. The relation between the molar concentration of the I, Gd or Ce contrast agent and the Hounsfield value was linear. Concentrations had to be sufficiently high to resolve the contrast agents.

中文翻译：

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关于从双能计算机断层扫描中的 CT 值中分辨出钆和铈基造影剂的可能性

已证明具有集成钆的氧化铈纳米颗粒可用作磁共振成像中的造影剂。值得怀疑的是它们在双能计算机断层扫描中的表现。这项工作的目的是确定 (1) 计算机断层扫描数与 I、Gd 或 Ce 造影剂浓度之间的关系，以及 (2) 在什么条件下可以确定造影剂的类型。使用 Siemens SOMATOM Definition Force 扫描仪在水体模中测量以 10、50 和 100 mM 摩尔浓度溶解在水中的碘乙酸、乙酸钆和乙酸铈的 Hounsfield 值；钆和醋酸铈被用作集成钆的氧化铈纳米颗粒的替代品。I的摩尔浓度之间的关系，Gd或Ce造影剂与Hounsfield值呈线性关系。浓度必须足够高以溶解造影剂。