ABSTRACT

Introduction

Molecular distillation (MD) is a physical separation method that was developed for several applications in petrochemical, food, cosmetics and pharmaceutical industries. Early industrial applications were most prominent in the petrochemical industry and in the food industry for vegetable oil refinement. During the past two decades, MD has gained a renewed attention and its applications have expanded to include purification and enrichment of bioactive compounds from natural product extracts and in nutraceuticals production.

Objectives

This review highlights, from a chemical perispective, applications and potential future MD development in the fields of pharmaceutics and natural product chemistry.

Literature review

A brief summary to outline the MD concept and the factors to be considered in designing efficient MD experiments is provided. Recent MD applications in the production and refinement of raw materials to be used in the pharmaceutical, cosmetics and nutraceutical industries are analyzed. This review further discusses future development in MD to expand its appliaction for refinement and purification of fixed oils, essential oils and plant extracts.

中文翻译：

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分子蒸馏在医药和食品行业的趋势和应用

摘要

介绍

分子蒸馏 (MD) 是一种物理分离方法，开发用于石化、食品、化妆品和制药行业的多种应用。早期的工业应用在石化工业和食品工业中用于植物油精炼最为突出。在过去的二十年中，MD 得到了新的关注，其应用范围已扩大到包括从天然产物提取物中纯化和富集生物活性化合物以及在保健品生产中。

目标

这篇综述从化学的角度突出了药物和天然产物化学领域的应用和潜在的未来 MD 发展。

文献综述

提供了概述 MD 概念和设计有效 MD 实验时要考虑的因素的简要总结。分析了用于制药、化妆品和保健品行业的原材料的生产和精炼中最近的 MD 应用。本综述进一步讨论了 MD 的未来发展，以扩大其在固定油、精油和植物提取物的提纯和纯化方面的应用。