Immunopathogenesis of oral submucous fibrosis by chewing the areca nut,Journal of Leukocyte Biology

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Immunopathogenesis of oral submucous fibrosis by chewing the areca nut
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-06-14 , DOI: 10.1002/jlb.3mr0521-763rr
Liping Wang ₁ , Zhangui Tang ₁

Affiliation

Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, and premalignant disease of the oral mucosa. Its pathogenic factors are complex and include chewing areca nuts or other spicy food items, nutrition, and genetic and immune factors. Recently, immune factors have become the focus of medical research, with increased attention being paid to the role of immune regulation in diseases, particularly tumors. OSF is accompanied by obvious changes in the immune microenvironment. The aim of this review is to discuss the potential relationship of OSF and areca nuts genetic with the immune system, including lymphocytes, macrophage, Langerhans cell, mast cell, and substances released by activated immune cells, to determine the pathogenesis and treatment of OSF from an immunologic viewpoint.

中文翻译：

咀嚼槟榔对口腔黏膜下纤维化的免疫发病机制

口腔黏膜下纤维化 (OSF) 是口腔黏膜的一种慢性、进行性、瘢痕形成和癌前病变。其致病因素复杂，包括咀嚼槟榔或其他辛辣食物、营养、遗传和免疫因素等。近年来，免疫因素成为医学研究的热点，免疫调节在疾病尤其是肿瘤中的作用受到越来越多的关注。OSF伴随着免疫微环境的明显变化。本综述旨在探讨 OSF 和槟榔遗传与免疫系统的潜在关系，包括淋巴细胞、巨噬细胞、朗格汉斯细胞、肥大细胞以及激活的免疫细胞释放的物质，以确定 OSF 的发病机制和治疗方法。免疫学观点。

更新日期：2021-06-14

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