Hesperidin, a phytoactive compound, is an abundant and economical dietary bioflavonoid possessing numerous biological and medicinal benefits. Several studies have strongly proven the significant chemotherapeutic potential of hesperidin. Therefore, this review aims to bring together the existing studies demonstrating hesperidin as a potential anticancer agent with its mode of action reported in the therapeutic strategies for numerous cancer types. Hesperidin acts via modulating multiple pathways involving cell cycle arrest, apoptosis, antiangiogenic, antimetastatic and DNA repair in various cancer cells. Hesperidin has been reported to alter several molecular targets related to carcinogenesis, such as reactive nitrogen species, cellular kinases, transcription factors, reactive oxygen species, drug transporters, cell cycle mediators and inflammatory cytokines. Collectively, this review provides significant insights for the potential of hesperidin to be a strong and promising candidate for pharmaceuticals, functional foods, dietary supplements, nutraceuticals and geared toward the better management of carcinoma.

橙皮苷是一种植物活性化合物，是一种丰富且经济的膳食生物类黄酮，具有多种生物学和药用价值。多项研究有力地证明了橙皮苷具有显着的化学治疗潜力。因此，本综述旨在汇集现有研究，证明橙皮苷是一种潜在的抗癌剂，其作用模式已在多种癌症类型的治疗策略中报道。橙皮苷通过调节多种途径发挥作用，这些途径涉及各种癌细胞中的细胞周期停滞、细胞凋亡、抗血管生成、抗转移和 DNA 修复。据报道，橙皮苷可以改变与致癌作用相关的几个分子靶点，例如活性氮、细胞激酶、转录因子、活性氧、药物转运蛋白、细胞周期介质和炎症细胞因子。总的来说，本综述为橙皮苷成为药物、功能性食品、膳食补充剂、营养保健品和更好地治疗癌症的强大而有前途的候选药物的潜力提供了重要的见解。