Abstract

The article is devoted to studying the synthesis of brominated nanodiamond and its reactivity with respect to N-nucleophiles (an antituberculous drug, isoniazid, and 2,4-dinitrophenylhydrazine). It has been shown that brominated surface of nanodiamond can be easily obtained by treating hydrogenated surface with bromine under heating and illumination with visible light. The work has resulted in the preparation of a nanodiamond–isoniazid conjugate as a potential drug for the treatment of tuberculosis.

中文翻译：

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溴化纳米金刚石作为异烟肼固定化平台

摘要

该文章致力于研究溴化纳米金刚石的合成及其与N-亲核试剂（一种抗结核药物、异烟肼和 2,4-二硝基苯肼）的反应性。研究表明，在加热和可见光照射下，用溴处理氢化表面可以很容易地获得纳米金刚石的溴化表面。这项工作导致制备了纳米金刚石-异烟肼偶联物，作为治疗结核病的潜在药物。