Abstract

During the last few decade, magnetite/hydroxyapatite nanoparticles have attracted much attention for its potential applications in the field of medicine and controlled drug delivery. In the present work, we have intended and synthesized, magnetite/hydroxyapatite nanoparticles by wet-chemical precipitation route. The thermal decomposition of the prepared sample was carried out by Thermogravimetric and Differential Scanning Calorimetry (TG/DSC) analysis upto 1000 °C, it showed that the sample was stable up to 919.2 °C. The phase formation, functional groups, morphology and magnetic property of as-prepared and annealed samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), micro Raman, Field Emission Scanning Electron Microscopy (FE-SEM), Transmission electron microscopy (TEM) and vibrating-sample magnetometer (VSM). By adopting Scherer method detailed structural analysis like the crystallite size, strain, dislocation density, lattice parameter, unit cell volume, surface area and fraction of crystallinity were calculated for as-prepared and annealed HA_P samples. The average crystallite size of the as-prepared, annealed at 700 °C, 800 °C and 900 °C are 39, 46, 51 and 65 nm, respectively. The dislocation density, strain and surface area were decreased. FT-IR and Raman spectra showed both as-prepared and annealed samples possessed the characteristic bands of HA_P. FE-SEM and TEM images depicted and confirmed the morphological characteristics of HA_P. The VSM analysis confirmed that both as-prepared and annealed samples of HA_P are in diamagnetic nature. The dielectric constant of as-prepared and annealed samples decreased with increase in annealing temperature whereas the conductivity increases with increase in frequency. The antibacterial property of apatite samples depending on the types of bacterial strains and also activity changed with the crystallite size.

摘要

在过去的几十年里，磁铁矿/羟基磷灰石纳米颗粒因其在医学和药物控制领域的潜在应用而备受关注。在目前的工作中，我们打算通过湿化学沉淀法合成磁铁矿/羟基磷灰石纳米颗粒。通过热重和差示扫描量热法 (TG/DSC) 分析，制备的样品在高达 1000 °C 的温度下进行热分解，表明该样品在高达 919.2 °C 时是稳定的。使用 X 射线衍射 (XRD)、傅里叶变换红外 (FTIR)、显微拉曼、场发射扫描电子显微镜 (FE-SEM) 表征制备和退火样品的相形成、官能团、形貌和磁性能，透射电子显微镜 (TEM) 和振动样品磁强计 (VSM)。通过采用 Scherer 方法，对制备和退火的 HA 计算了微晶尺寸、应变、位错密度、晶格参数、晶胞体积、表面积和结晶度分数等详细结构分析_P样本。在 700 °C、800 °C 和 900 °C 下退火的所制备的平均微晶尺寸分别为 39、46、51 和 65 nm。位错密度、应变和表面积降低。FT-IR 和拉曼光谱表明制备的和退火的样品都具有 H _P的特征带。FE-SEM 和 TEM 图像描绘并证实了 H _P的形态特征。VSM 分析证实，HA _{P 的}制备和退火样品具有抗磁性。制备和退火样品的介电常数随着退火温度的增加而降低，而电导率随着频率的增加而增加。磷灰石样品的抗菌性能取决于细菌菌株的类型，并且活性随晶粒大小而变化。