Research on the mechanical properties of brain tissue has received extensive attention. However, most of the current studies have been conducted at the phenomenological level. In this study, the indentation method was used to explore the difference in local mechanical properties among different regions of the porcine cerebral cortex. Further, hematoxylin-eosin and immunofluorescence staining methods were used to determine the correlation between the cellular density at different test points and mechanical properties of the porcine cerebral cortex. The frontal lobe exhibited the strongest viscosity. The temporal lobe displayed the lowest sensitivity to changes in the indentation speed, and the occipital lobe exhibited the highest shear modulus. Additionally, the shear modulus of different areas of the cerebral cortex was negatively correlated with the total number of local cells per unit area and positively correlated with the number of neuronal cell bodies per unit area. Exploration of the mechanical properties of the local brain tissue can provide basic data for the establishment of a finite element model of the brain and mechanical referential information for the implantation position of brain chips.

脑组织力学特性的研究受到广泛关注。然而，目前的大多数研究都是在现象学水平上进行的。本研究采用压痕法探讨了猪大脑皮层不同区域局部力学性能的差异。此外，还采用苏木精-伊红染色和免疫荧光染色方法确定了不同测试点的细胞密度与猪大脑皮层力学性能之间的相关性。额叶表现出最强的粘性。颞叶对压痕速度变化的敏感性最低，枕叶的剪切模量最高。此外，大脑皮层不同区域的剪切模量与单位面积局部细胞总数呈负相关，与单位面积神经元细胞体数量呈正相关。探索局部脑组织的力学特性，可为建立大脑有限元模型提供基础数据，为脑芯片植入位置提供力学参考信息。