Mimicking compositional and constructional features of the extracellular matrix (ECM) is an effective parameter in improving the biological response of biomaterials. In this regard, carbon nanotube (CNT) and gelatin were added to magnesium-calcium phosphate cement (CNG) to mimic fibrillar construction and organic composition of ECM, respectively, besides the CNG performance was compared with the plain and CNT-reinforced cement. Cementation behavior of the cements was investigated by evaluating their setting time, cement composition variation during setting, and viscosity fluctuation. Furthermore, compressive strength, degradation, and cell response of the cements were compared. Adding 5 wt.% gelatin reduced setting time about 60%, because of gel formation, not due to struvite precipitation. Moreover, the gelatin decreased compressive strength by about 20%. Although gelatin decreased compressive strength, the strength remained in the range attributed to trabecular bone. All the types of cement indicated shear thinning behavior that made their injectability feasible. Compared to other types of cement, CNG enhanced proliferation and differentiation of mesenchymal stem cells besides faster degradation, nontoxicity and suitable cell adhesion. Hence, mimicking features of CNG enhanced osteoconductivity and osteoinductivity of the cement compared to the plain one.

模拟细胞外基质 (ECM) 的组成和结构特征是改善生物材料生物反应的有效参数。在这方面，将碳纳米管 (CNT) 和明胶添加到磷酸镁钙水泥 (CNG) 中，分别模拟 ECM 的纤维结构和有机成分，此外还比较了 CNG 性能与普通和 CNT 增强水泥。通过评估水泥的凝结时间、凝结过程中水泥成分的变化和粘度波动来研究水泥的胶结行为。此外，还比较了水泥的抗压强度、降解和细胞响应。添加 5 wt.% 的明胶减少了约 60% 的凝固时间，这是因为凝胶形成，而不是由于鸟粪石沉淀。而且，明胶使抗压强度降低了约 20%。虽然明胶降低了抗压强度，但强度仍保持在归因于小梁骨的范围内。所有类型的水泥都表现出剪切稀化行为，这使得它们的可注射性变得可行。与其他类型的水泥相比，CNG 增强了间充质干细胞的增殖和分化，此外还具有更快的降解、无毒和合适的细胞粘附。因此，与普通水泥相比，模仿 CNG 的特性增强了水泥的骨传导性和骨诱导性。除了更快的降解、无毒性和合适的细胞粘附外，CNG 还增强了间充质干细胞的增殖和分化。因此，与普通水泥相比，模仿 CNG 的特性增强了水泥的骨传导性和骨诱导性。除了更快的降解、无毒性和合适的细胞粘附外，CNG 还增强了间充质干细胞的增殖和分化。因此，与普通水泥相比，模仿 CNG 的特性增强了水泥的骨传导性和骨诱导性。