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Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-06-10 , DOI: 10.1111/cns.13694
Le Ma 1, 2 , Shiyu Peng 2, 3 , Jinbao Wei 1 , Mengjing Zhao 1 , Khalil Ali Ahmad 1 , Jinghong Chen 2 , Yong-Xiang Wang 1
Affiliation  

This study aimed to investigate the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interleukin (IL)-10 and glucagon-like peptide 1 receptor (GLP-1R) agonist exenatide-induced pain anti-hypersensitivity in neuropathic rats through spinal nerve ligations.

中文翻译:

脊髓小胶质细胞β-内啡肽信号介导IL-10和艾塞那肽诱导的神经性疼痛中突触可塑性的抑制

本研究旨在探讨白细胞介素(IL)-10和胰高血糖素样肽1受体(GLP-1R)激动剂艾塞那肽通过脊神经对神经性大鼠疼痛抗过敏的脊髓突触传递机制诱导的疼痛超敏反应的调节作用。结扎。
更新日期:2021-06-10
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